CAS Number2566-90-7
Synonymsall-cis-4,7,10,13,16,19-docosahexaenoic acid methyl ester; Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate; Methyl (4E,7E,10E,13E,16E,19E)-4,7,10,13,16,19-docosahexaenoate; Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoate; DHA methyl ester; Docosahexaenoic acid methyl; methyl 4,7,10,13,16,19-docosahexaenoate; all-cis-4,7,10,13,16,19-Docosahexaenoic acid methyl ester solution
Molecular FormulaCH3(CH2CH=CH)6CH2CH2CO2CH3
Molecular Weight342.51
Density0.9±0.1 g/cm3
Boiling Point429.9±24.0 °C at 760 mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2566-90-7 |
| Catalog No. | 2A-2188450 |
| Chinese Name | 二十二六烯酸甲酯 |
| Synonyms | all-cis-4,7,10,13,16,19-docosahexaenoic acid methyl ester; Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate; Methyl (4E,7E,10E,13E,16E,19E)-4,7,10,13,16,19-docosahexaenoate; Methyl (4Z,7Z,10Z,13Z,16Z,19Z)-4,7,10,13,16,19-docosahexaenoate; DHA methyl ester; Docosahexaenoic acid methyl; methyl 4,7,10,13,16,19-docosahexaenoate; all-cis-4,7,10,13,16,19-Docosahexaenoic acid methyl ester solution |
| Molecular Formula | CH3(CH2CH=CH)6CH2CH2CO2CH3 |
| Molecular Weight | 342.51 |
| Density | 0.9±0.1 g/cm3 |
| Boiling Point | 429.9±24.0 °C at 760 mmHg |
| Storage Condition | −20°C |
| Application | Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog that can be inserted into membrane phospholipids without being oxidized or hydrolyzed. |
| HTC | 29161900 |
| PubChem ID | 24893705 |
| MDL Number | MFCD00673450 |
| SMILES | CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC |
| InChI | InChI=1S/C23H34O2/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23(24)25-2/h4-5,7-8,10-11,13-14,16-17,19-20H,3,6,9,12,15,18,21-22H2,1-2H3/b5-4-,8-7-,11-10-,14-13-,17-16-,20-19- |
| InChI Key | VCDLWFYODNTQOT-JDPCYWKWSA-N |
| NACRES Code | NA.25 |
| UNSPSC | 12352211 |
| Hazard Symbols | 3.0 |
| Bioactivity | Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vitro Sharp wave (SPW) incidence relative to baseline appears to decrease following Docosahexaenoic Acid methyl ester (DHA-Me) application[1]. There is no generation of a new protein band when bovine serum albumin (BSA) is exposed to the Fe2+ and ascorbic acid (AsA) mixed-function oxidation system in the absence of Docosahexaenoic Acid methyl ester (DHA). However, the high-molecular-weight protein band is observed after only 24 h when BSA is incubated with DHA. Incubation of BSA with 1.0 mM DHA leads to a substantial increase in protein carbonyl content and the addition of oxygen radical scavengers leads to a substantial decrease in protein carbonyl content[2]. Kinase Assay Protein (1 mg/mL) is incubated with Docosahexaenoic Acid methyl ester (DHA) (1.0 mM) in 50 mM HEPES buffer (pH 7.4) containing 0.2% (w/v) of Tween 20 at 37°C. Mannitol, histidine, sodium benzoate, or KI is added at final concentration of 0.5 M, 0.2 M, 0.5 M, or 0.1 M, respectively. Reactive oxygen species are generated by addition of FeSO4 (1 μM) and ascorbic acid (AsA, 20 μM)[2]. References [1]. Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17. [2]. Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66. Chemical & Physical Properties Density 0.9±0.1 g/cm3 Boiling Point 429.9±24.0 °C at 760 mmHg Molecular Formula C23H34O2 Molecular Weight 342.515 Flash Point 103.9±21.2 °C Exact Mass 342.255890 PSA 26.30000 LogP 7.24 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.505 InChIKey VCDLWFYODNTQOT-JDPCYWKWSA-N SMILES CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC Storage condition −20°C |
| Use of | Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed. Properties Name Docosahexaenoic Acid methyl ester Synonym More Synonyms Docosahexaenoic Acid methyl ester Biological Activity Description Docosahexaenoic Acid methyl ester is a methylated docosahexaenoic acid analog which can be intercalated into membrane phospholipids without being oxidized or hydrolyzed. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Taha AY, et al. Selective reduction of excitatory hippocampal sharp waves by docosahexaenoic acid and its methyl ester analog ex-vivo. Brain Res. 2013 Nov 6;1537:9-17. [2]. Liu W, et al. Formation of high-molecular-weight protein adducts by methyl docosahexaenoate peroxidation products. Biochim Biophys Acta. 2007 Feb;1774(2):258-66. Chemical & Physical Properties Molecular Formula C23H34O2 Exact Mass 342.255890 PSA 26.30000 Index of Refraction 1.505 InChIKey VCDLWFYODNTQOT-JDPCYWKWSA-N SMILES CCC=CCC=CCC=CCC=CCC=CCC=CCCC(=O)OC |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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