EN
0
Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > QUINOMYCIN A
QUINOMYCIN A structure, CAS 512-64-1

QUINOMYCIN A

CAS Number512-64-1

Synonymsechinomycin; quinomycin-A

Molecular FormulaC51H64N12O12S2

Molecular Weight1101.26000

Purity

Density1.41 g/cm3

Boiling Point1427.2ºC at 760 mmHg

Melting Point

Flash Point

Appearance

EINECS

MSDSChineseEnglish

Symbol6.1(b)

Signal WordWarning

Cat. No.: 2A-2188235 Purity:
Change View

Please Login or Create an Account to: See VlP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

Inquiry

Quality Control of [ 512-64-1 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number512-64-1
Catalog No.2A-2188235
Chinese Name棘霉素
Synonymsechinomycin; quinomycin-A
Molecular FormulaC51H64N12O12S2
Molecular Weight1101.26000
Density1.41 g/cm3
Boiling Point1427.2ºC at 760 mmHg
Storage Condition-20°C, dry, sealed
PackagingIII
ApplicationEchinomycin (Quinomycin A) is a potent, cell-permeable, small molecule inhibitor of the DNA-binding activity of hypoxia-inducible factor-1 (HIF-1). Echinomycin selectively inhibits cancer stem cells w
PubChem ID11534317
SMILESCSC1SCC2C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c1cnc3ccccc3n1)C(=O)NC(C)C(=O)N2C
InChIInChI=1S/C51H64N12O12S2/c1-25(2)38-49(72)74-22-36(59-42(65)34-21-53-30-17-13-15-19-32(30)57-34)44(67)55-28(6)46(69)63(10)40-48(71)62(9)39(26(3)4)50(73)75-23-35(58-41(64)33-20-52-29-16-12-14-18-31(29)56-33)43(66)54-27(5)45(68)60(7)37(47(70)61(38)8)24-77-51(40)76-11/h12-21,25-28,35-40,51H,22-24H2,1-11H3,(H,54,66)(H,55,67)(H,58,64)(H,59,65)
InChI KeyAUJXLBOHYWTPFV-UJILECMYSA-N
Hazard Symbols6.1(b)
BioactivityEchinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. Related Catalog Research Areas >> Cancer In Vitro Echinomycin (0-10 nM; 16 hours; U251 cells) treatment significantly inhibits hypoxia-induced VEGF mRNA expression in a dose-dependent fashion. Echinomycin very potently inhibits hypoxic induction of luciferase expression in U251-HRE in a dose-dependent fashion with an EC50 of 1.2 nM[1]. RT-PCR[1] Cell Line: U251 cells Concentration: 0 nM, 0.625 nM, 1.25 nM, 5 nM, 10 nM Incubation Time: 16 hours Result: Significantly inhibited VEGF mRNA expression induced by hypoxia in a dose-dependent fashion. In Vivo Echinomycin (10 μg/kg; intravenous injection; for 40 days; NOD-SCID mice) treatment efficiently eradicates mouse lymphoma and serially transplantable human acute myeloid leukemia (AML) in xenogeneic model by preferential elimination of cancer stem cells (CSCs). HIF1α maintains mouse lymphoma CSCs by repressing a negative feedback loop in the Notch pathway[2]. Animal Model: NOD-SCID mice received 1.8Gy of irradiation and i.v. injection with peripheral blood cells from patients AML-71 and AML-150[2] Dosage: 10 μg/kg Administration: Intravenous injection; for 40 days Result: Efficiently eradicated mouse lymphoma and serially transplantable human AML in xenogeneic model by preferential elimination of CSCs. References [1]. Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65(19):9047-55. [2]. Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8(4):399-411. Chemical & Physical Properties Density 1.41 g/cm3 Boiling Point 1427.2ºC at 760 mmHg Molecular Formula C51H64N12O12S2 Molecular Weight 1101.26000 Flash Point 817ºC Exact Mass 1100.42000 PSA 352.40000 LogP 1.82630 Index of Refraction 1.536 InChIKey AUJXLBOHYWTPFV-UJILECMYSA-N SMILES CSC1SCC2C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c3cnc4ccccc4n3)C(=O)NC(C)C(=O)N(C)C1C(=O)N(C)C(C(C)C)C(=O)OCC(NC(=O)c1cnc3ccccc3n1)C(=O)NC(C)C(=O)N2C
Use ofEchinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. Properties Articles28 Name quinomycin a Synonym More Synonyms Echinomycin Biological Activity Description Echinomycin (Quinomycin A) is potent small-molecule and cell-permeable inhibitor of hypoxia-inducible factor-1 (HIF-1) DNA-binding activity. Echinomycin selectively inhibits the cancer stem cells (CSCs) with an IC50 of 29.4 pM[1][2]. Related Catalog Research Areas >> Cancer In Vivo Echinomycin (10 μg/kg; intravenous injection; for 40 days; NOD-SCID mice) treatment efficiently eradicates mouse lymphoma and serially transplantable human acute myeloid leukemia (AML) in xenogeneic model by preferential elimination of cancer stem cells (CSCs). HIF1α maintains mouse lymphoma CSCs by repressing a negative feedback loop in the Notch pathway[2]. Animal Model: NOD-SCID mice received 1.8Gy of irradiation and i.v. injection with peripheral blood cells from patients AML-71 and AML-150[2] Dosage: 10 μg/kg Administration: Intravenous injection; for 40 days Result: Efficiently eradicated mouse lymphoma and serially transplantable human AML in xenogeneic model by preferential elimination of CSCs. References [1]. Kong D, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005 Oct 1;65(19):9047-55. [2]. Wang Y, et al. Targeting HIF1α eliminates cancer stem cells in hematological malignancies. Cell Stem Cell. 2011 Apr 8;8(4):399-411. Chemical & Physical Properties Molecular Formula C51H64N12O12S2 Exact Mass 1100.42000 PSA 352.40000 LogP 1.82630 Index of Refraction 1.536 InChIKey AUJXLBOHYWTPFV-UJILECMYSA-N
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Danger Regulations: 3462 International Maritime Transport Danger Regulations: 3462 International Air Transport Danger Regulations: 3462 14.2 United Nations shipping name European Land Transport Dangerous Regulations: TOXINS EXTRAC TED FROM LIVING SOURCES, SOLID, N.O.S. (Echinomycin) IMDG: TOXINS, EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. International air transport hazard regulations: Toxins, extracted from living sources, solid, n.o.s. (Echinomycin) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
Related Products in Specialty Chemicals
Rezafungin1396640-59-72A-2188230
Basifungin127785-64-22A-2188231
PUROMYCIN53-79-22A-2188232
Naphthomycin55557-40-92A-2188233
Rhodomycin A23666-50-42A-2188234
tallysomycin67995-68-02A-2188236
Pactamycin23668-11-32A-2188237
Olivomycin11006-70-52A-2188238
Duocarmycin A118292-34-52A-2188239
ANSAMITOCIN DERIV72902-38-62A-2188241
Browse all Specialty Chemicals products »
Contact Us

Phone:

630-322-8886

630-322-8887

Email:

[email protected]

Office Locations:

Chicago, IL, USA

San Francisco, CA, USA