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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > BERBAMINE DIHYDROCHLORIDE
BERBAMINE DIHYDROCHLORIDE structure, CAS 6078-17-7

BERBAMINE DIHYDROCHLORIDE

CAS Number6078-17-7

Synonyms6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol hydrochloride (1:1); MFCD01076588; berbamine dihydrochloride

Molecular FormulaC37H42Cl2N2O6

Molecular Weight681.66

Purity

Density

Boiling Point744.4ºC at 760 mmHg

Melting Point250-253ºC(lit.)

Flash Point

Appearance

EINECS

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Cat. No.: 2A-2187822 Purity:
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Quality Control of [ 6078-17-7 ] SDS Specification MoL

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Chemical & Physical Properties
CAS Number6078-17-7
Catalog No.2A-2187822
Chinese Name盐酸小檗胺
Synonyms6,6',7-Trimethoxy-2,2'-dimethylberbaman-12-ol hydrochloride (1:1); MFCD01076588; berbamine dihydrochloride
Molecular FormulaC37H42Cl2N2O6
Molecular Weight681.66
Boiling Point744.4ºC at 760 mmHg
Melting Point250-253ºC(lit.)
Storage ConditionStore in an airtight, cool and dry place, ensuring
ApplicationBerbamine dihydrochloride is an NF-κB inhibitor with significant anti-myeloma efficacy.
HTC2933990090
PubChem ID24878760
MDL NumberC37H42Cl2N2O6
SMILESCOc1cc2c3cc1Oc1c(OC)c(OC)cc4c1C(Cc1ccc(O)c(c1)Oc1ccc(cc1)CC3N(C)CC2)N(C)CC4.Cl.Cl
InChIInChI=1S/C37H40N2O6.2ClH/c1-38-14-12-24-19-32(41-3)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-31-18-23(8-11-30(31)40)17-29-35-25(13-15-39(29)2)20-34(42-4)36(43-5)37(35)45-33;;/h6-11,18-21,28-29,40H,12-17H2,1-5H3;2*1H/t28-,29+;;/m0../s1
InChI KeyUSRXDYNDPPUBSG-KKXMJGKMSA-N
Use ofBerbamine dihydrochloride is an inhibitor of NF-κB activity with remarkable anti-myeloma efficacy. Properties Articles25 Name Berbaminedihydrochloride Synonym More Synonyms Berbamine hydrochloride Biological Activity Description Berbamine dihydrochloride is an inhibitor of NF-κB activity with remarkable anti-myeloma efficacy. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Natural Products >> Alkaloid Research Areas >> Cancer References [1]. Liang Y, et al. Berbamine, a novel nuclear factor kappaB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sin. 2009 Dec;30(12):1659-65. [2]. Meng Z, et al. Berbamine inhibits the growth of liver cancer cells and cancer-initiating cells by targeting Ca2+/calmodulin-dependent protein kinase II. Mol Cancer Ther. 2013 Oct;12(10):2067-77. Chemical & Physical Properties PSA 72.86000 LogP 7.53720 InChIKey USRXDYNDPPUBSG-KKXMJGKMSA-N Safety Information Signal Word Warning Hazard Statements H302-H315-H319-H335 Precautionary Statements P261-P305 + P351 + P338 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves Hazard Codes Xn Safety Phrases S26-S36 RIDADR NONH for all modes of transport WGK Germany 3 HS Code 2933990090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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