CAS Number24502-79-2
Synonyms(BETA,BETA-DIMETHYLACRYL)SHIKONIN; dmask; Senecioylshikonin; Dimethylacrylshikonin; Isoarnebin I; b,b-Dimethylacrylshikonin; 5,8-Dihydroxy-2-[(1R,3E)-1-hydroxy-4,8-dimethyl-6-oxo-3,7-nonadien-1-yl]-1,4-naphthoquinone; (β,β-DiMethylacryl)shikonin
Molecular FormulaC21H22O6
Molecular Weight370.40
Purity98.00%%
Density1.3±0.1 g/cm3
Boiling Point653.2±55.0 °C at 760 mmHg
Melting Point103ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 24502-79-2 |
| Catalog No. | 2A-4187724 |
| Chinese Name | β,β-二甲基丙烯酰紫草素 |
| Synonyms | (BETA,BETA-DIMETHYLACRYL)SHIKONIN; dmask; Senecioylshikonin; Dimethylacrylshikonin; Isoarnebin I; b,b-Dimethylacrylshikonin; 5,8-Dihydroxy-2-[(1R,3E)-1-hydroxy-4,8-dimethyl-6-oxo-3,7-nonadien-1-yl]-1,4-naphthoquinone; (β,β-DiMethylacryl)shikonin |
| Molecular Formula | C21H22O6 |
| Molecular Weight | 370.40 |
| Purity | 98.00% |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 653.2±55.0 °C at 760 mmHg |
| Melting Point | 103ºC |
| Application | β,β-Dimethylacrylshikonin is a naphthoquinone derivative extracted from Arnebia nobilis. It induces the expression of eNOS, VEGF and HIF-1α through the PI3K pathway and promotes angiogenesis. Arnebin |
| HTC | 2916129000 |
| PubChem ID | 10309110 |
| MDL Number | MFCD00143687 |
| SMILES | CC(C)=CCC(OC(=O)C=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O |
| InChI | InChI=1S/C21H22O6/c1-11(2)5-8-17(27-18(25)9-12(3)4)13-10-16(24)19-14(22)6-7-15(23)20(19)21(13)26/h5-7,9-10,17,22-23H,8H2,1-4H3 |
| InChI Key | BATBOVZTQBLKIL-QGZVFWFLSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Bioactivity | β,β-Dimethylacrylshikonin is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Arnebin 1 has anti-tumor activity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97. [2]. Sidhu GS, et al. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999 Nov;113(5):773-81. Chemical & Physical Properties Density 1.3±0.1 g/cm3 Boiling Point 653.2±55.0 °C at 760 mmHg Melting Point 103ºC Molecular Formula C21H22O6 Molecular Weight 370.396 Flash Point 362.8±28.0 °C Exact Mass 370.141632 PSA 100.90000 LogP 4.45 Vapour Pressure 0.0±2.1 mmHg at 25°C Index of Refraction 1.616 InChIKey BATBOVZTQBLKIL-QGZVFWFLSA-N SMILES CC(C)=CCC(OC(=O)C=C(C)C)C1=CC(=O)c2c(O)ccc(O)c2C1=O |
| Use of | β,β-Dimethylacrylshikonin is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Arnebin 1 has anti-tumor activity[1]. Properties Name (β,β-DIMETHYLACRYL)SHIKONIN Synonym More Synonyms Dimethylacrylshikonin Biological Activity Description β,β-Dimethylacrylshikonin is a naphthoquinone derivative isolated from Arnebia nobilis, promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Arnebin 1 has anti-tumor activity[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others References [1]. Zeng Z, et al. Arnebin-1 promotes angiogenesis by inducing eNOS, VEGF and HIF-1α expression through the PI3K-dependent pathway. Int J Mol Med. 2015 Sep;36(3):685-97. [2]. Sidhu GS, et al. Arnebin-1 accelerates normal and hydrocortisone-induced impaired wound healing. J Invest Dermatol. 1999 Nov;113(5):773-81. Chemical & Physical Properties Molecular Formula C21H22O6 Exact Mass 370.141632 PSA 100.90000 Index of Refraction 1.616 InChIKey BATBOVZTQBLKIL-QGZVFWFLSA-N |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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