CAS Number112-60-7
Synonyms2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol; 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol; Tetra(ethylene glycol); 2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol; MFCD00002879; Tetraglycol; Ethyl acetate; Tetraethylene glycol; 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol; EINECS 203-989-9; Bis[2-(2-hydroxyethoxy)ethyl] ether; Bis[2-(2-hydroxyethoxy)ethyl]ether; tetraethylene glycol-; tetraethyleneglycol; PEG-4
Molecular FormulaHO(CH2CH2O)3CH2CH2OH
Molecular Weight194.23
Purity99%
Density1.1±0.1 g/cm3
Boiling Point314 °C (lit.)
Melting Point−5.6 °C (lit.)
AppearanceColorless to light yellow liquid
EINECS203-989-9
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 112-60-7 |
| Catalog No. | 2A-9018877 |
| Chinese Name | 三缩四乙二醇 |
| Synonyms | 2,2'-[Oxybis(2,1-ethanediyloxy)]diethanol; 2,2'-((Oxybis(ethane-2,1-diyl))bis(oxy))diethanol; Tetra(ethylene glycol); 2,2'-[Oxybis(ethane-2,1-diyloxy)]diethanol; MFCD00002879; Tetraglycol; Ethyl acetate; Tetraethylene glycol; 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethanol; EINECS 203-989-9; Bis[2-(2-hydroxyethoxy)ethyl] ether; Bis[2-(2-hydroxyethoxy)ethyl]ether; tetraethylene glycol-; tetraethyleneglycol; PEG-4 |
| Molecular Formula | HO(CH2CH2O)3CH2CH2OH |
| Molecular Weight | 194.23 |
| Purity | 99 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 314 °C (lit.) |
| Melting Point | −5.6 °C (lit.) |
| Appearance | Colorless to light yellow liquid |
| Water Solubility | soluble |
| Storage Condition | Store in a cool, ventilated warehouse. Keep away f |
| Application | PROTAC Linker 18 is a PROTAC link bridge, belonging to the alkyl/ether class. PROTAC Linker 18 can be used to synthesize a range of PROTAC molecules. PROTAC molecules contain two different ligands con |
| EINECS | 203-989-9 |
| HTC | 2942000000 |
| PubChem ID | 24846965 |
| MDL Number | MFCD00002879 |
| SMILES | OCCOCCOCCOCCO |
| InChI | 1S/C8H18O5/c9-1-3-11-5-7-13-8-6-12-4-2-10/h9-10H,1-8H2 |
| InChI Key | UWHCKJMYHZGTIT-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1634320 |
| NACRES Code | NA.23 |
| eCl@ss | 39020714 |
| UNSPSC | 12162002 |
| MSDS | msds/18877_1_112_60_7.pdf |
| Bioactivity | PROTAC Linker 18 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 18 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Target Alkyl/ether References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 328.0±0.0 °C at 760 mmHg Melting Point -5.6 °C(lit.) Molecular Formula C8H18O5 Molecular Weight 194.225 Flash Point 176.7±0.0 °C Exact Mass 194.115417 PSA 68.15000 LogP -2.23 Vapour density 6.7 (vs air) Vapour Pressure 0.0±1.6 mmHg at 25°C Index of Refraction 1.455 InChIKey UWHCKJMYHZGTIT-UHFFFAOYSA-N SMILES OCCOCCOCCOCCO Stability Stable. Incompatible with strong oxidizing agents, strong bases. Water Solubility soluble |
| Use of | Properties Articles14 Name tetraethylene glycol Synonym More Synonyms Biological Activity Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl/ether References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. Chemical & Physical Properties Molecular Formula C8H18O5 Exact Mass 194.115417 PSA 68.15000 LogP -2.23 Vapour density 6.7 (vs air) Index of Refraction 1.455 InChIKey UWHCKJMYHZGTIT-UHFFFAOYSA-N SMILES OCCOCCOCCOCCO Stability Stable. Incompatible with strong oxidizing agents, strong bases. Water Solubility soluble |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Chemical name |
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| 1-Dodecanol | 112-53-8 | 2A-9018873 |
| 1-Dodecanethiol | 112-55-0 | 2A-9018875 |
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