![2-(Hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one structure, CAS 5291-32-7](/structures/210000/188425_1_5291_32_7.png)
CAS Number5291-32-7
Synonyms2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one; UNII-Z41TGB4080; 3-Quinuclidinone,2-(hydroxymethyl)-2-(methoxymethyl); 2-Methoxymethyl-2-methylol-3-chinuclidinon; APR-246; 2-hydroxymethyl-2-methoxymethyl-1-aza-bicyclo[2.2.2]octan-3-one; UNII:Z41TGB4080
Molecular FormulaC10H17NO3
Molecular Weight199.247
Density1.2±0.1 g/cm3
Boiling Point313.8±17.0 °C at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 5291-32-7 |
| Catalog No. | 2A-2187090 |
| Chinese Name | PRIMA-1Met |
| Synonyms | 2-(Hydroxymethyl)-2-(methoxymethyl)quinuclidin-3-one; UNII-Z41TGB4080; 3-Quinuclidinone,2-(hydroxymethyl)-2-(methoxymethyl); 2-Methoxymethyl-2-methylol-3-chinuclidinon; APR-246; 2-hydroxymethyl-2-methoxymethyl-1-aza-bicyclo[2.2.2]octan-3-one; UNII:Z41TGB4080 |
| Molecular Formula | C10H17NO3 |
| Molecular Weight | 199.247 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 313.8±17.0 °C at 760 mmHg |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | PRIMA-1MET is a mutant p53 reactivator that restores the wild-type conformation and function of mutant p53 and triggers tumor cell apoptosis. PRIMA-1MET also inhibits the selenoprotein thioredoxin red |
| HTC | 2933990090 |
| SMILES | COCC1(C(=O)C2CCN1CC2)CO |
| InChI | InChI=1S/C10H17NO3/c1-14-7-10(6-12)9(13)8-2-4-11(10)5-3-8/h8,12H,2-7H2,1H3 |
| InChI Key | BGBNULCRKBVAKL-UHFFFAOYSA-N |
| Use of | PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. Properties Name 2-(hydroxymethyl)-2-(methoxymethyl)-1-azabicyclo[2.2.2]octan-3-one Synonym More Synonyms APR-246 Biological Activity Description PRIMA-1MET restores wild-type conformation and function to mutant p53, and triggers apoptosis in tumor cells. PRIMA-1MET also targets the selenoprotein thioredoxin reductase 1 (TrxR1), a key regulator of cellular redox balance. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Cancer p53 activator[1] TrxR1 inhibitor[1] References [2]. Stuber G, et al. PRIMA-1MET induces nucleolar translocation of Epstein-Barr virus-encoded EBNA-5 protein. Mol Cancer. 2009 Mar 26;8:23. Chemical & Physical Properties Molecular Formula C10H17NO3 Exact Mass 199.120850 PSA 49.77000 Index of Refraction 1.537 InChIKey BGBNULCRKBVAKL-UHFFFAOYSA-N Storage condition -20℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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