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Home > Products > Specialty & Industrial Chemicals > Specialty Chemicals > 3'-SIALYLLACTOSE / Colostrum Milk
3'-SIALYLLACTOSE / Colostrum Milk structure, CAS 35890-38-1

3'-SIALYLLACTOSE / Colostrum Milk

CAS Number35890-38-1

SynonymsN-acetylneuraminoyllactose; 3'-Sialyllactose; 3'-sialyllactose; 3'-Sialyllactose (3'-SL); 32-N-Acetyl-a-neuraminyllactose; 3'-N-Acetylneuraminyl-D-lactose; 3'-Monosialyllactose; 3'-a-Sialyllactose; N-acetylneuraminosyl-D-lactose; 3'-Sialyl-D-lactose; a2,3-Sialyllactose

Molecular FormulaC23H39NO19

Molecular Weight633.55100

Purity98%

Density1.72 g/cm3

Boiling Point1132.8ºC at 760 mmHg

Melting Point

Flash Point

Appearance

EINECS

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Cat. No.: 2A-4186996 Purity: 98%
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Quality Control of [ 35890-38-1 ] Purity: 98% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number35890-38-1
Catalog No.2A-4186996
Chinese Name3'-唾液乳糖钠盐
SynonymsN-acetylneuraminoyllactose; 3'-Sialyllactose; 3'-sialyllactose; 3'-Sialyllactose (3'-SL); 32-N-Acetyl-a-neuraminyllactose; 3'-N-Acetylneuraminyl-D-lactose; 3'-Monosialyllactose; 3'-a-Sialyllactose; N-acetylneuraminosyl-D-lactose; 3'-Sialyl-D-lactose; a2,3-Sialyllactose
Molecular FormulaC23H39NO19
Molecular Weight633.55100
Purity98
Density1.72 g/cm3
Boiling Point1132.8ºC at 760 mmHg
Storage Condition−20°C
Application3'-Sialyllactose (3'-SL) is a prebiotic that maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-sialyllactose can be used in inflammation research [1][2].
SMILESCC(=O)NC1C(O)CC(OC2C(O)C(CO)OC(OC(C(O)CO)C(O)C(O)C=O)C2O)(C(=O)O)OC1C(O)C(O)CO
InChI KeyOIZGSVFYNBZVIK-FHHHURIISA-N
Hazard Symbolstransportation
Bioactivity3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2]. Related Catalog Research Areas >> Inflammation/Immunology In Vitro 3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1]. 3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1]. Western Blot Analysis[1] Cell Line: Chondrocytes Concentration: 0, 50, 100 and 250 μM Incubation Time: 24-36 hours Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3,Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes. In Vivo 3'-Sialyllactose (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1]. Animal Model: 8-week-old male C57BL/6 mice with medial meniscus surgery[1] Dosage: 10, 50 and 100 mg/kg Administration: Oral gavage; 10-100 mg/kg three times a week; for 6 weeks Result: Effectively protected osteoarthritis mice against cartilage destruction by catabolic factor expression. References [1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66. [2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603. Chemical & Physical Properties Density 1.72 g/cm3 Boiling Point 1132.8ºC at 760 mmHg Molecular Formula C23H39NO19 Molecular Weight 633.55100 Flash Point 638.9ºC Exact Mass 633.21200 PSA 342.92000 InChIKey OIZGSVFYNBZVIK-FHHHURIISA-N SMILES CC(=O)NC1C(O)CC(OC2C(O)C(CO)OC(OC(C(O)CO)C(O)C(O)C=O)C2O)(C(=O)O)OC1C(O)C(O)CO Storage condition −20°C
Use of3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2]. Properties Articles30 Name (2S,4S,5R,6R)-5-acetamido-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid Synonym More Synonyms 3'-sialyllactose Biological Activity Description 3'-Sialyllactose (3'-SL) is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose can be used for the research of inflammation[1][2]. Related Catalog Research Areas >> Inflammation/Immunology In Vitro 3'-Sialyllactose (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1]. 3'-Sialyllactose (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1]. Western Blot Analysis[1] Cell Line: Chondrocytes Concentration: 0, 50, 100 and 250 μM Incubation Time: 24-36 hours Result: Dose-dependently increased Col2a1 transcript and protein levels, and restored Col2a1 expression in IL-1β-treated chondrocytes. Dose-dependently inhibited IL-1β-induced Mmp3,Mmp13 and Cox2 expression in chondrocytes. Reduced expression of Mmp3, Mmp13 and Cox2 induced by IL-6, IL-17 and TNF-α in chondrocytes. References [1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66. [2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603. Chemical & Physical Properties Molecular Formula C23H39NO19 Exact Mass 633.21200 PSA 342.92000 InChIKey OIZGSVFYNBZVIK-FHHHURIISA-N
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MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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