| Chemical & Physical Properties | |
|---|---|
| CAS Number | 6809-70-7 |
| Catalog No. | 2A-3186983 |
| Chinese Name | 十一甘醇 |
| Synonyms | EINECS 229-884-8; 3,6,9,12,15,18,21,24,27,30-Decaoxadotriacontane-1,32-diol; Undecaethylene glycol |
| Molecular Formula | C22H46O12 |
| Molecular Weight | 502.6 |
| Density | 1.116g/cm3 |
| Boiling Point | 571.4ºC at 760 mmHg |
| Storage Condition | 2-8°C, dry |
| Application | HO-PEG11-OH is a PROTAC linker, belonging to the PEG category. Can be used to synthesize PROTAC molecules. |
| HTC | 2909499000 |
| PubChem ID | 10218500 |
| MDL Number | MFCD26793839 |
| SMILES | OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO |
| InChI | InChI=1S/C22H46O12/c23-1-3-25-5-7-27-9-11-29-13-15-31-17-19-33-21-22-34-20-18-32-16-14-30-12-10-28-8-6-26-4-2-24/h23-24H,1-22H2 |
| InChI Key | PSVXZQVXSXSQRO-UHFFFAOYSA-N |
| Use of | HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Properties Name 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Synonym More Synonyms HO-PEG11-OH Biological Activity Description HO-PEG11-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. References [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 Chemical & Physical Properties Molecular Formula C22H46O12 Exact Mass 502.29900 PSA 132.76000 Index of Refraction 1.465 InChIKey PSVXZQVXSXSQRO-UHFFFAOYSA-N SMILES OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO Safety Information HS Code 2909499000 Synthetic Route 1,36-diphenyl-2... CAS#:349113-91-3 HO-PEG11-OH CAS#:6809-70-7 Literature: Ahmed, Saleh A.; Tanaka, Mutsuo Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9884 - 9886 BnO-PEG5-OH CAS#:57671-28-0 HO-PEG11-OH CAS#:6809-70-7 Literature: Krishnamurthy, Vijay M.; Semetey, Vincent; Bracher, Paul J.; Shen, Nan; Whitesides, George M. Journal of the American Chemical Society, 2007 , vol. 129, # 5 p. 1312 - 1320 2,2'-((Oxybis(e... CAS#:112-60-7 HO-PEG11-OH CAS#:6809-70-7 Literature: Ahmed, Saleh A.; Tanaka, Mutsuo Journal of Organic Chemistry, 2006 , vol. 71, # 26 p. 9884 - 9886 Precursor & DownStream Precursor 5 CAS#:349113-91-3 1,36-diphenyl-2... CAS#:57671-28-0 BnO-PEG5-OH CAS#:112-60-7 2,2'-((Oxybis(e... CAS#:86259-87-2 Tetraethylene G... DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2909499000. ether-alcohols and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:5.5%. General tariff:30.0% |
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