CAS Number1094-08-2
Synonymsisothazinehydrochloride; ProphenamineHCl; parsidolhydrochloride; EINECS 214-134-4; ethopropazine hydrochloride; Profenaminhydrochlorid; 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE; parfezin; lysivanehydrochloride; ethopropazine hcl; MFCD00012653
Molecular FormulaC19H25ClN2S
Molecular Weight348.93
Boiling Point430.1ºC at 760 mmHg
Melting Point225 - 228 °C
Appearancewhite powder
EINECS214-134-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1094-08-2 |
| Catalog No. | 2A-3186933 |
| Chinese Name | 盐酸乙丙嗪 |
| Synonyms | isothazinehydrochloride; ProphenamineHCl; parsidolhydrochloride; EINECS 214-134-4; ethopropazine hydrochloride; Profenaminhydrochlorid; 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE; parfezin; lysivanehydrochloride; ethopropazine hcl; MFCD00012653 |
| Molecular Formula | C19H25ClN2S |
| Molecular Weight | 348.93 |
| Boiling Point | 430.1ºC at 760 mmHg |
| Melting Point | 225 - 228 °C |
| Appearance | white powder |
| Storage Condition | 1. Storage conditions 2-8°C |
| Application | Ethoxypromazine hydrochloride (isooxazine) is a potent and selective BChE inhibitor and a poor acetylcholinesterase inhibitor. Ethoxypromazine hydrochloride is a phenothiazine compound with anticholin |
| EINECS | 214-134-4 |
| PubChem ID | 329799070 |
| MDL Number | MFCD00012653 |
| SMILES | [H+].[Cl-].CCN(CC)C(C)CN1c2ccccc2Sc3ccccc13 |
| InChI | InChI=1S/C19H24N2S.ClH/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21;/h6-13,15H,4-5,14H2,1-3H3;1H |
| InChI Key | InChIKey=VXPCQISYVPFYRK-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| Bioactivity | Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor. Ethopropazine hydrochloride is a phenothiazine compound with anticholinergic properties. Ethopropazine hydrochloride can be used for the research of Parkinson's disease[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE Target BChE, AChE[2] References [1]. Prabhu S, et al. Enhancement of dissolution of ethopropazine using solid dispersions prepared with phospholipid and/or polyethylene glycol. Drug Dev Ind Pharm. 2001 May;27(5):413-8. [2]. Reiner E, et al. Activity of cholinesterases in human whole blood measured with acetylthiocholine as substrate and ethopropazine as selective inhibitor of plasma butyrylcholinesterase. Arh Hig Rada Toksikol. 2004 Apr;55(1):1-4. Chemical & Physical Properties Boiling Point 430.1ºC at 760 mmHg Melting Point 225 - 228 °C Molecular Formula C19H25ClN2S Molecular Weight 348.93300 Flash Point 213.9ºC Exact Mass 348.14300 PSA 31.78000 LogP 5.88660 Vapour Pressure 1.34E-07mmHg at 25°C Storage condition 2-8°C |
| Use of | Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor. Ethopropazine hydrochloride is a phenothiazine compound with anticholinergic properties. Ethopropazine hydrochloride can be used for the research of Parkinson's disease[1][2]. Properties Articles73 Name profenamine hydrochloride Synonym More Synonyms 10-[2-DIETHYLAMINOPROPYL]PHENOTHIAZINE Biological Activity Description Ethopropazine (Isothazine) hydrochloride is a potent, selective BChE inhibitor and a poor AChE inhibitor. Ethopropazine hydrochloride is a phenothiazine compound with anticholinergic properties. Ethopropazine hydrochloride can be used for the research of Parkinson's disease[1][2]. Related Catalog Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE BChE, AChE[2] References [1]. Prabhu S, et al. Enhancement of dissolution of ethopropazine using solid dispersions prepared with phospholipid and/or polyethylene glycol. Drug Dev Ind Pharm. 2001 May;27(5):413-8. [2]. Reiner E, et al. Activity of cholinesterases in human whole blood measured with acetylthiocholine as substrate and ethopropazine as selective inhibitor of plasma butyrylcholinesterase. Arh Hig Rada Toksikol. 2004 Apr;55(1):1-4. Chemical & Physical Properties Exact Mass 348.14300 PSA 31.78000 LogP 5.88660 |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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