CAS Number36062-05-2
SynonymsHexahydrocurcumin; 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one; 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone; (RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone
Molecular FormulaC21H26O6
Molecular Weight374.43
Density1.2±0.1 g/cm3
Boiling Point622.6±55.0 °C at 760 mmHg
Melting Point80-82℃
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 36062-05-2 |
| Catalog No. | 2A-3186798 |
| Chinese Name | 六氢姜黄素 |
| Synonyms | Hexahydrocurcumin; 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)heptan-3-one; 5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone; (RS)-5-Hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-3-heptanone |
| Molecular Formula | C21H26O6 |
| Molecular Weight | 374.43 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 622.6±55.0 °C at 760 mmHg |
| Melting Point | 80-82℃ |
| Storage Condition | -20°C |
| Application | Hexahydrocurcumin is a natural compound with anti-cancer and anti-inflammatory activities and a COX-2 selective inhibitor. |
| HTC | 2914509090 |
| PubChem ID | 11057791 |
| InChI | InChI=1S/C21H26O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,16,22,24-25H,3-4,7-8,13H2,1-2H3 |
| InChI Key | RSAHICAPUYTWHW-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Hexahydrocurcumin is a natural compound which posesses anticancer and anti-inflammatory activities; selective COX-2 inhibitor.IC50 value:Target: in vitro: The relative antioxidant potencies of ginger compounds decreased in similar order of 1-dehydro-[6]-gingerdione, hexahydrocurcumin>6-shogaol>6-dehydroshogaol in both 1,1-diphenyl-2-picyrlhydrazyl (DPPH) radical-scavenging and trolox equivalent antioxidant capacity (TEAC) assays [1]. HHC alone markedly decreased the viability of HT-29 human colon cancer cells compared to control. HHC significantly down-regulates COX-2 mRNA expression compared to the control (control: 100.05% ± 0.03% vs HHC: 61.01% ± 0.35%, P < 0.05) but does not alter COX-1 mRNA. In combined treatment, addition of HHC to a low dose of 5-FU exerts a synergistic effect against the growth of HT-29 cells by markedly reducing cell viability to a greater degree than monotherapy [2].in vivo: The combined effects of HHC with 5-FU exhibit a synergistic inhibition by decreasing ACF formation mediated by down-regulation of COX-2 expression in rats [3]. Related Catalog Research Areas >> Cancer Natural Products >> Phenols References [1]. Li F, et al. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem. 2012 Nov 15;135(2):332-7. [2]. Srimuangwong K, et al. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9. [3]. Srimuangwong K, et al. Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats. World J Gastroenterol. 2012 Dec 21;18(47):6951-9. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 622.6±55.0 °C at 760 mmHg Melting Point 80-82℃ Molecular Formula C21H26O6 Molecular Weight 374.427 Flash Point 218.4±25.0 °C Exact Mass 374.172943 PSA 96.22000 LogP 1.49 Vapour Pressure 0.0±1.9 mmHg at 25°C Index of Refraction 1.583 Storage condition -20°C |
| Use of | Properties Name Hexahydrocurcumin Synonym More Synonyms Hexahydrocurcumin Biological Activity Related Catalog Research Areas >> Cancer Natural Products >> Phenols References [1]. Li F, et al. In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin. Food Chem. 2012 Nov 15;135(2):332-7. [2]. Srimuangwong K, et al. Hexahydrocurcumin enhances inhibitory effect of 5-fluorouracil on HT-29 human colon cancer cells. World J Gastroenterol. 2012 May 21;18(19):2383-9. [3]. Srimuangwong K, et al. Effects of hexahydrocurcumin in combination with 5-fluorouracil on dimethylhydrazine-induced colon cancer in rats. World J Gastroenterol. 2012 Dec 21;18(47):6951-9. Chemical & Physical Properties Molecular Formula C21H26O6 Exact Mass 374.172943 PSA 96.22000 Index of Refraction 1.583 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 5.5% Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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