| Chemical & Physical Properties | |
|---|---|
| CAS Number | 56985-40-1 |
| Catalog No. | 2A-1186591 |
| Chinese Name | 9,11-二脱氧基-9α,11α-亚甲基环氧前列腺素 F2α溶液 |
| Synonyms | MFCD00135238 |
| Molecular Formula | C21H34O4 |
| Molecular Weight | 350.49 |
| Purity | 98.00 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 519.7±30.0 °C at 760 mmHg |
| Storage Condition | Seal and store at -20ºC |
| Application | U-46619 (9,11-Methanoepoxy PGH2) is a stable analog of thromboxane A2 (TXA2) and a potent TXA2 agonist. |
| PubChem ID | 24894197 |
| MDL Number | MFCD00135238 |
| SMILES | CCCCC[C@H](O)/C=C/[C@@H]1[C@@H]2C[C@H](CO2)C1C\C=C/CCCC(O)=O |
| InChI | InChI=1S/C21H34O4/c1-2-3-6-9-17(22)12-13-19-18(16-14-20(19)25-15-16)10-7-4-5-8-11-21(23)24/h4,7,12-13,16-20,22H,2-3,5-6,8-11,14-15H2,1H3,(H,23,24)/b7-4-,13-12+/t16-,17+,18?,19+,20+/m1/s1 |
| InChI Key | InChIKey=LQANGKSBLPMBTJ-WTPHSRJXSA-N |
| Beilstein/REAXYS | 4267334 |
| NACRES Code | NA.77 |
| UNSPSC | 12352211 |
| Hazard Symbols | transportation |
| Bioactivity | U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Target TXA2[1] In Vitro U-46619 (1 nM-10 μM) causes platelets shape change and aggregation in a concentration-dependent manner, and with EC50s of 0.58 μM and 0.013 μM for aggregation and shape change, respectively[1]. U-46619 (10 nM-10 μM) increases internal Ca2+ concentration ([Ca2+]i) and activates phosphoinositide (PI) hydrolysis in a concentration-dependent manner with a similar concentration-dependency[1]. U-46619 (3 nM-10 μM) also activates GTPase concentration-dependently in the membranes derived from platelets[1]. U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways[2]. In Vivo U-46619 (5 μg/kg; i.v.) increases blood pressure in male spontaneously hypertensive rats (SHR)[3]. Animal Model: 12-15 weeks-old male and female SHR[2] Dosage: 5 μg/kg Administration: Intravenous injection Result: Induceed a significant increase of MABP after 1 min in male SHR. References [1]. Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104. [2]. Su L, et al. The prostaglandin H2 analog U-46619 improves the differentiation efficiency of human induced pluripotent stem cells into endothelial cells by activating both p38MAPK and ERK1/2 signaling pathways. Stem Cell Res Ther. 2018 Nov 15;9(1):313. [3]. Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 519.7±30.0 °C at 760 mmHg Molecular Formula C21H34O4 Molecular Weight 350.492 Flash Point 176.1±18.1 °C Exact Mass 350.245697 PSA 66.76000 LogP 3.90 Vapour Pressure 0.0±3.1 mmHg at 25°C Index of Refraction 1.548 |
| Use of | U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1]. Properties Articles82 Name 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α Synonym More Synonyms U-46619 Biological Activity Description U-46619 (9,11-Methanoepoxy PGH2) is a stable analogue of thromboxane A2 (TXA2) and acts as a potent TXA2 agonist[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor References [1]. Ohkubo S, et al. Thromboxane A2-mediated shape change: independent of Gq-phospholipase C--Ca2+ pathway in rabbit platelets. Br J Pharmacol. 1996 Mar;117(6):1095-104. [3]. Schirner M, et al. U 46619 induces different blood pressure effects in male and female spontaneously hypertensive rats (SHR). Prostaglandins Leukot Essent Fatty Acids. 1993 Jun;48(6):469-73. Chemical & Physical Properties Molecular Formula C21H34O4 Exact Mass 350.245697 PSA 66.76000 Index of Refraction 1.548 |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 1231 International Dangerous Regulations for sea transport: 1231 International Dangerous Regulations for air transport: 1231 14.2 United Nations shipping name EUROGRO: METHYL ACETATE, SOLUTION IMDG Code: METHYL ACETATE, SOLUTION IFRS: Methyl acetate, solution 14.3 Transport hazard categories European land transport Dangerous Regulations: 3 International sea transport Dangerous Regulations: 3 International air transport Dangerous Regulations: 3 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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