CAS Number101622-51-9
SynonymsOLO; olomoucine; 2-{[6-(Benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol; MFCD00189360; 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine
Molecular FormulaC15H18N6O
Molecular Weight298.34
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point579.6±60.0 °C at 760 mmHg
Melting Point120-130 °C
AppearanceWhite crystalline powder
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 101622-51-9 |
| Catalog No. | 2A-1186321 |
| Chinese Name | 2-(2'-羟基乙基氨基)-9-甲基-6-(苄基氨基)嘌呤 |
| Synonyms | OLO; olomoucine; 2-{[6-(Benzylamino)-9-methyl-9H-purin-2-yl]amino}ethanol; MFCD00189360; 2-(6-Benzylamino-9-methyl-9H-purin-2-ylamino)-ethanol Olomoucine |
| Molecular Formula | C15H18N6O |
| Molecular Weight | 298.34 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 579.6±60.0 °C at 760 mmHg |
| Melting Point | 120-130 °C |
| Appearance | White crystalline powder |
| Storage Condition | Store airtight in a cool, dry warehouse. Refrigera |
| Application | Olomoucine is an ATP-competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative that inhibits the activity of CDC2/cyclin B, Cdk2/cyclin a, Cdk2/cyclin E (IC50=7 µM), CDK/p35 kinase ( |
| PubChem ID | 511554 |
| SMILES | Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21 |
| InChI | InChI=1S/C15H18N6O/c1-21-10-18-12-13(17-9-11-5-3-2-4-6-11)19-15(16-7-8-22)20-14(12)21/h2-6,10,22H,7-9H2,1H3,(H2,16,17,19,20) |
| InChI Key | GTVPOLSIJWJJNY-UHFFFAOYSA-N |
| Hazard Symbols | transportation |
| Bioactivity | Olomoucine is an ATP competitive inhibitor of CDKs. Olomoucine is a purine (HY-34431) derivative and inhibits CDC2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E (both IC50=7 µM), CDK/p35 kinase (IC50=3 µM) and ERK1/p44 MAP kinase (IC50=25 µM)[1][2]. Related Catalog Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> CDK Target cdk2-cyclin A:7 μM (IC50) cdk2-cyclin E:7 μM (IC50) References [1]. Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994). [2]. 2.Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995). Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 579.6±60.0 °C at 760 mmHg Melting Point 120-130 °C Molecular Formula C15H18N6O Molecular Weight 298.343 Flash Point 304.3±32.9 °C Exact Mass 298.154205 PSA 87.89000 LogP -0.08 Vapour Pressure 0.0±1.7 mmHg at 25°C Index of Refraction 1.691 InChIKey GTVPOLSIJWJJNY-UHFFFAOYSA-N SMILES Cn1cnc2c(NCc3ccccc3)nc(NCCO)nc21 Storage condition −20°C |
| Use of | Properties Name 2-[[6-(benzylamino)-9-methylpurin-2-yl]amino]ethanol Synonym More Synonyms Olomoucine Biological Activity Related Catalog Research Areas >> Others Signaling Pathways >> Cell Cycle/DNA Damage >> CDK cdk2-cyclin A:7 μM (IC50) cdk2-cyclin E:7 μM (IC50) References [1]. Vesely, J., Havlicek, J., Strnad, M., et al. Inhibition of cyclin-dependent kinases by purine analogues. European Journal of Biochemistry 224, 771-786 (1994). [2]. 2.Abraham, R.T., Acquarone, M., Andersen, A., et al. Cellular effects of olomoucine, an inhibitor of cyclin-dependent kinases. Biology of the Cell 83(2), 105-120 (1995). Chemical & Physical Properties Molecular Formula C15H18N6O Exact Mass 298.154205 PSA 87.89000 LogP -0.08 Index of Refraction 1.691 InChIKey GTVPOLSIJWJJNY-UHFFFAOYSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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