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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride
1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride structure, CAS 76778-22-8

1-(2-Diphenylmethoxyethyl)-4-(3-phenylpropyl)piperazinedihydrochloride

CAS Number76778-22-8

Synonyms1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-but-2-enedioate (1:1); Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, (2Z)-2-butenedioate (1:1); 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-2-butenedioate (1:1); 1-(2-benzhydryloxy-ethyl)-4-(3-phenyl-propyl)-piperazine; Piperazine,1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl); 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine; 1-(2-(diphenylmethoxy)-ethyl)-4-(3-phenylpropyl)piperazine; 1-(2-(Benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine maleate; GBR 12935

Molecular FormulaC28H34N2O

Molecular Weight414.58

Purity

Density1.067g/cm3

Boiling Point540.6ºC at 760 mmHg

Melting Point

Flash Point

Appearance

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Cat. No.: 2A-3186212 Purity:
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Chemical & Physical Properties
CAS Number76778-22-8
Catalog No.2A-3186212
Chinese NameGBR 12935
Synonyms1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-but-2-enedioate (1:1); Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)-, (2Z)-2-butenedioate (1:1); 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine (2Z)-2-butenedioate (1:1); 1-(2-benzhydryloxy-ethyl)-4-(3-phenyl-propyl)-piperazine; Piperazine,1-(2-(diphenylmethoxy)ethyl)-4-(3-phenylpropyl); 1-Hydrocinnamyl-4-[2-(diphenylmethoxy)ethyl]piperazine; 1-(2-(diphenylmethoxy)-ethyl)-4-(3-phenylpropyl)piperazine; 1-(2-(Benzhydryloxy)ethyl)-4-(3-phenylpropyl)piperazine maleate; GBR 12935
Molecular FormulaC28H34N2O
Molecular Weight414.58
Density1.067g/cm3
Boiling Point540.6ºC at 760 mmHg
Storage Condition2-8℃
ApplicationGBR 12935 is a dopamine reuptake inhibitor.
HTC2933599090
PubChem ID5006249
SMILESO=C(O)C=CC(=O)O.c1ccc(CCCN2CCN(CCOC(c3ccccc3)c3ccccc3)CC2)cc1
InChIInChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2
InChI KeyQCSMGOCTDJAWRQ-WLHGVMLRSA-N
Use ofProperties Name 1-[2-(benzhydryloxy)ethyl]-4-(3-phenylpropyl)piperazine Synonym More Synonyms GBR 12935 Biological Activity Related Catalog Signaling Pathways >> Neuronal Signaling >> Dopamine Transporter Research Areas >> Neurological Disease References [1]. Hiroi T, et al. Specific binding of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl propyl) piperazine (GBR-12935), an inhibitor of the dopamine transporter, to human CYP2D6. Biochem Pharmacol. 1997 Jun 15;53(12):1937-9. [2]. Rahman S, et al. Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens. Eur J Pharmacol. 2001 Feb 23;414(1):37-44. [3]. Tolliver BK, et al. Comparison of cocaine and GBR 12935: effects on locomotor activity and stereotypy in two inbred mouse strains. Pharmacol Biochem Behav. 1994 Jul;48(3):733-9. Chemical & Physical Properties Molecular Formula C28H34N2O PSA 90.31000 LogP 4.63060 Index of Refraction 1.576 InChIKey QCSMGOCTDJAWRQ-WLHGVMLRSA-N Storage condition 2-8℃ Safety Information HS Code 2933599090
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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