CAS Number118409-57-7
Synonyms2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile; (3,4-dihydroxybenzylidene)propanedinitrile; MFCD00133899; (3,4-Dihydroxybenzylidene)malononitrile RG-50810; (3,4-Dihydroxybenzylidene)malononitrile; AG 18; AG-18
Molecular FormulaC10H6N2O2
Molecular Weight186.17
Purity98.00%
Density1.4±0.1 g/cm3
Boiling Point421.1±45.0 °C at 760 mmHg
Melting Point225ºC
AppearanceYellow-tawny solid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 118409-57-7 |
| Catalog No. | 2A-1186161 |
| Chinese Name | (3,4-二羟基苄基)丙二腈 |
| Synonyms | 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile; (3,4-dihydroxybenzylidene)propanedinitrile; MFCD00133899; (3,4-Dihydroxybenzylidene)malononitrile RG-50810; (3,4-Dihydroxybenzylidene)malononitrile; AG 18; AG-18 |
| Molecular Formula | C10H6N2O2 |
| Molecular Weight | 186.17 |
| Purity | 98.00 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 421.1±45.0 °C at 760 mmHg |
| Melting Point | 225ºC |
| Appearance | Yellow-tawny solid |
| Water Solubility | Soluble in DMSO, ethanol, or DMF |
| Storage Condition | Sealed, store at 2 ºC -8 ºC |
| Application | Tyrphostin 23 (Tyrphostin A23) is an inhibitor of EGFR with an IC50 value of 35 μM. |
| PubChem ID | 24278041 |
| MDL Number | MFCD00133899 |
| SMILES | N#CC(C#N)=Cc1ccc(O)c(O)c1 |
| InChI | InChI=1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H |
| InChI Key | VTJXFTPMFYAJJU-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| Bioactivity | Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively. Related Catalog Research Areas >> Cancer Target EGFR:35 μM (IC50, Cell Assay) EGFR:11 μM (Ki) In Vitro 10 μM tyrphostin 23 causes significant inhibition of the cell proliferation caused by 1 nM and 1μM ghrelin[2]. Tyrphostin 23 (T23) is a well-known inhibitor of protein tyrosine kinases and has been considered as potential anti-cancer drug. T23 is reported to acutely stimulate the glycolytic flux in primary cultured astrocytes. Tyrphostin 23 stimulates glycolytic flux in cultured astrocytes. Mitochondrial metabolism of brain astrocytes is accelerated by Tyrphostin 23 exposure[3]. References [1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40. [3]. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21. Chemical & Physical Properties Density 1.4±0.1 g/cm3 Boiling Point 421.1±45.0 °C at 760 mmHg Melting Point 225ºC Molecular Formula C10H6N2O2 Molecular Weight 186.167 Flash Point 208.5±28.7 °C Exact Mass 186.042923 PSA 88.04000 LogP 0.99 Vapour Pressure 0.0±1.0 mmHg at 25°C Index of Refraction 1.697 InChIKey VTJXFTPMFYAJJU-UHFFFAOYSA-N SMILES N#CC(C#N)=Cc1ccc(O)c(O)c1 Storage condition 2-8°C Water Solubility Soluble in DMSO, ethanol, or DMF |
| Use of | Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively. Properties Articles29 Name Tyrphostin 23 Synonym More Synonyms AG 18 Biological Activity Description Tyrphostin 23 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively. Related Catalog Research Areas >> Cancer EGFR:35 μM (IC50, Cell Assay) EGFR:11 μM (Ki) References [1]. Gazit A, et al. Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors. J Med Chem. 1989 Oct;32(10):2344-52. [2]. Nanzer AM, et al. Ghrelin exerts a proliferative effect on a rat pituitary somatotroph cell line via the mitogen-activated protein kinase pathway. Eur J Endocrinol. 2004 Aug;151(2):233-40. [3]. Hohnholt MC, et al. The tricarboxylic acid cycle activity in cultured primary astrocytes is strongly accelerated by the protein tyrosine kinase inhibitor tyrphostin 23. Neurochem Int. 2017 Jan;102:13-21. Chemical & Physical Properties Molecular Formula C10H6N2O2 Exact Mass 186.042923 PSA 88.04000 Index of Refraction 1.697 InChIKey VTJXFTPMFYAJJU-UHFFFAOYSA-N Water Solubility Soluble in DMSO, ethanol, or DMF |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip. |
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