CAS Number341-88-8
SynonymsHOQNO; 2-Heptylquinolin-4-ol 1-oxide; 2 heptyl 4 hydroxyquinoline 1 oxide; 4-Quinolinol,2-heptyl-,1-oxide; 2-heptyl-1-hydroxyquinolin-4-one; 2-Heptyl-4-quinolinol 1-oxide; HQNO; 4-Quinolinol, 2-heptyl-, 1-oxide; 2-heptyl-4-hydroxyquinoline n-oxide
Molecular FormulaC16H21O2N1
Molecular Weight259.35
Density1.1±0.1 g/cm3
Boiling Point445.8±37.0 °C at 760 mmHg
Melting Point156-157ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 341-88-8 |
| Catalog No. | 2A-3185314 |
| Chinese Name | 2-庚基-4-羟基喹啉1-氧化物 |
| Synonyms | HOQNO; 2-Heptylquinolin-4-ol 1-oxide; 2 heptyl 4 hydroxyquinoline 1 oxide; 4-Quinolinol,2-heptyl-,1-oxide; 2-heptyl-1-hydroxyquinolin-4-one; 2-Heptyl-4-quinolinol 1-oxide; HQNO; 4-Quinolinol, 2-heptyl-, 1-oxide; 2-heptyl-4-hydroxyquinoline n-oxide |
| Molecular Formula | C16H21O2N1 |
| Molecular Weight | 259.35 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 445.8±37.0 °C at 760 mmHg |
| Melting Point | 156-157ºC |
| Storage Condition | Room temperature, inert gas storage |
| Application | HQNO, produced by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd value of 64 nM for complex III. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species. |
| HTC | 2933499090 |
| PubChem ID | 6946 |
| MDL Number | MFCD00057295 |
| SMILES | CCCCCCCc1cc(=O)c2ccccc2n1O |
| InChI | InChI=1S/C16H21NO2/c1-2-3-4-5-6-9-13-12-16(18)14-10-7-8-11-15(14)17(13)19/h7-8,10-12,19H,2-6,9H2,1H3 |
| InChI Key | ICTVCUOZYWNYHM-UHFFFAOYSA-N |
| Use of | HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2]. Properties Name 2-heptyl-4-hydroxyquinoline N-oxide Synonym More Synonyms HQNO Biological Activity Description HQNO, secreted by P. aeruginosa, is a potent electron transport chain inhibitor with a Kd of 64 nM for complex III[1]. HQNO is a potent inhibitor of mitochondrial NDH-2 in many species[2]. Related Catalog Research Areas >> Infection References [1]. N J Jacobs, et al. Evidence for Involvement of the Electron Transport System at a Late Step of Anaerobic Microbial Heme Synthesis. Biochim Biophys Acta. 1977 Jan 6;459(1):141-4. [2]. Jessica Petri, et al. Structure of the NDH-2 - HQNO Inhibited Complex Provides Molecular Insight Into Quinone-Binding Site Inhibitors. Biochim Biophys Acta Bioenerg. 2018 Jul;1859(7):482-490. Chemical & Physical Properties Molecular Formula C16H21NO2 Exact Mass 259.157227 PSA 42.23000 Index of Refraction 1.558 InChIKey ICTVCUOZYWNYHM-UHFFFAOYSA-N Safety Information Hazard Codes Xi RTECS VC5890000 HS Code 2933499090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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