| Chemical & Physical Properties | |
|---|---|
| CAS Number | 152918-18-8 |
| Catalog No. | 2A-3185295 |
| Chinese Name | 匹利诺生 |
| Synonyms | UNII-30679UMI0N; Piclidenoson; IBMECA; CF 101; 3-IB-Meca; IB-MECA; CF101 |
| Molecular Formula | C18H19IN6O4 |
| Molecular Weight | 544.73 |
| Density | 2.0±0.1 g/cm3 |
| Storage Condition | 2-8°C, protected from light, dry and sealed |
| Application | Piclidenoson (IB-MECA) is an adenosine A 3 receptor agonist with an EC50 value of 0.11 μM. |
| HTC | 2934999090 |
| PubChem ID | 24278354 |
| MDL Number | MFCD01861178 |
| SMILES | CNC(=O)C1OC(n2cnc3c(NCc4cccc(I)c4)ncnc32)C(O)C1O |
| InChI | InChI=1S/C18H19IN6O4/c1-20-17(28)14-12(26)13(27)18(29-14)25-8-24-11-15(22-7-23-16(11)25)21-6-9-3-2-4-10(19)5-9/h2-5,7-8,12-14,18,26-27H,6H2,1H3,(H,20,28)(H,21,22,23)/t12-,13+,14-,18+/m0/s1 |
| InChI Key | HUJXGQILHAUCCV-MOROJQBDSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Use of | Properties Articles32 Name (2S,3S,4R,5R)-3,4-dihydroxy-5-[6-[(3-iodophenyl)methylamino]purin-9-yl]-N-methyloxolane-2-carboxamide Synonym More Synonyms IB-MECA Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor Research Areas >> Cancer References [1]. Hofer M, et al. Agonist of the adenosine A3 receptor, IB-MECA, and inhibitor of cyclooxygenase-2, meloxicam, given alone or in a combination early after total body irradiation enhance survival of γ-irradiated mice. Radiat Environ Biophys. 2014 Mar;53(1):211-215. [2]. Abedi H, et al. Mitochondrial and caspase pathways are involved in the induction of apoptosis by IB-MECA in ovarian cancer cell lines. Tumour Biol. 2014 Nov;35(11):11027-11039. [3]. Shin Y, et al. Activation of Phosphoinositide Breakdown and Elevation of Intracellular Calcium in a Rat RBL-2H3 Mast Cell Line by Adenosine Analogs: Involvement of A(3)-Adenosine Receptors? Drug Dev Res. 1996 Sep 1;39(1):36-46. Chemical & Physical Properties Molecular Formula C18H19IN6O4 Exact Mass 510.051239 PSA 134.42000 Index of Refraction 1.808 InChIKey HUJXGQILHAUCCV-MOROJQBDSA-N Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR NONH for all modes of transport HS Code 2934999090 Synthetic Route Benzylamine, m-... CAS#:3718-88-5 CAS#:152918-18-8 Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 1-(6-Chloro-9H-... CAS#:104940-65-0 CAS#:152918-18-8 Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 1-(6-Chloro-9H-... CAS#:152918-47-3 CAS#:152918-18-8 Literature: Journal of Medicinal Chemistry, , vol. 37, # 5 p. 636 - 646 Precursor & DownStream Precursor 5 CAS#:3718-88-5 Benzylamine, m-... CAS#:104940-65-0 1-(6-Chloro-9H-... CAS#:152918-47-3 1-(6-Chloro-9H-... CAS#:696-41-3 3-Iodobenzaldehyde DownStream 1 CAS#:163042-96-4 2-CL-IB-MECA |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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