| Chemical & Physical Properties | |
|---|---|
| CAS Number | 151978-50-6 |
| Catalog No. | 2A-3185293 |
| Chinese Name | N-Boc-4-pentyne-1-amine |
| Synonyms | tert-butyl N-pent-4-ynylcarbamate |
| Molecular Formula | C10H17NO2 |
| Molecular Weight | 183.25 |
| Storage Condition | Room temperature, sealed, dry |
| Application | N-Boc-4-pentyne-1-amine is a PROTAC linker and belongs to the alkyl chain class. N-Boc-4-pentyne-1-amine can be used in the synthesis of PROTAC MG-277 (HY-130122). |
| HTC | 2924199090 |
| PubChem ID | 329768002 |
| MDL Number | MFCD20036287 |
| InChI | InChI=1S/C10H17NO2/c1-5-6-7-8-11-9(12)13-10(2,3)4/h1H,6-8H2,2-4H3,(H,11,12) |
| InChI Key | JTPJJKZSKWNWKK-UHFFFAOYSA-N |
| Beilstein/REAXYS | 6918435 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Use of | N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1]. Properties Name N-Boc-4-pentyne-1-amine Synonym More Synonyms tert-Butyl pent-4-yn-1-ylcarbamate Biological Activity Description N-Boc-4-pentyne-1-amine is a PROTAC linker, which refers to the alkyl chain composition. N-Boc-4-pentyne-1-amine can be used in the synthesis of the PROTAC MG-277 (HY-130122)[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker Alkyl-Chain References [1]. Yang J, et al. Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. J Med Chem. 2019 Oct 21. Chemical & Physical Properties Molecular Formula C10H17NO2 Exact Mass 183.12600 PSA 41.82000 LogP 2.12890 Safety Information Signal Word Danger Hazard Statements H314 Precautionary Statements P280-P305 + P351 + P338-P310 Hazard Codes C HS Code 2924199090 Synthetic Route Di-tert-butyl d... CAS#:24424-99-5 4-Pentyn-1-amine CAS#:15252-44-5 tert-Butyl pent... CAS#:151978-50-6 5-Hexynoic acid CAS#:53293-00-8 tert-Butanol CAS#:75-65-0 tert-Butyl pent... CAS#:151978-50-6 Literature: Synthesis, , # 9 art. no. Z17611SS, p. 1477 - 1483 4-Cyano-1-butyne CAS#:19596-07-7 tert-Butyl pent... CAS#:151978-50-6 Literature: Organic Letters, , vol. 9, # 15 p. 2887 - 2889 Precursor & DownStream Precursor 8 CAS#:24424-99-5 Di-tert-butyl d... CAS#:15252-44-5 4-Pentyn-1-amine CAS#:53293-00-8 5-Hexynoic acid CAS#:75-65-0 tert-Butanol DownStream 2 CAS#:131667-57-7 N-Boc-3,4-dihyd... CAS#:202925-92-6 Carbamic acid, ... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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