CAS Number125256-00-0
SynonymsHexatype Brown N; Typogen Brown N; Resinol RRN; Solvent Brown 1; fatostatin A; Sudan Brown YR; Sudan Brown RR; Fat Brown RR; 1-naphthylamin->m-phenylendiamin; C.I. Solvent Brown 1; 4-naphthalen-1-yl-diazenyl-benzene-1,3-diamine; Lithofor Brown A
Molecular FormulaC18H18N2S1
Molecular Weight294.42
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 125256-00-0 |
| Catalog No. | 2A-1184525 |
| Chinese Name | 脂肪抑素A. |
| Synonyms | Hexatype Brown N; Typogen Brown N; Resinol RRN; Solvent Brown 1; fatostatin A; Sudan Brown YR; Sudan Brown RR; Fat Brown RR; 1-naphthylamin->m-phenylendiamin; C.I. Solvent Brown 1; 4-naphthalen-1-yl-diazenyl-benzene-1,3-diamine; Lithofor Brown A |
| Molecular Formula | C18H18N2S1 |
| Molecular Weight | 294.42 |
| Storage Condition | 2-8℃ |
| Application | Fatostatin is an inhibitor of SREBP that can bind to SCAP and prevent its ER-to-Golgi transport. The IC50 in mammals is between 2.5 and 10 uM. |
| HTC | 2934100090 |
| MDL Number | MFCD02376000 |
| SMILES | CCCc1cc(-c2nc(-c3ccc(C)cc3)cs2)ccn1 |
| InChI Key | ZROSUBKIGBSZCG-UHFFFAOYSA-N |
| Use of | Properties Name 4-[4-(4-Methylphenyl)-1,3-thiazol-2-yl]-2-propylpyridine Synonym More Synonyms Fatostatin A Biological Activity Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer References [1]. Li X et al. Fatostatin displays high antitumor activity in prostate cancer by blocking SREBP-regulated metabolic pathways and androgen receptor signaling. Mol Cancer Ther. 2014 Apr;13(4):855-66. [2]. Shao W et al. Fatostatin blocks ER exit of SCAP but inhibits cell growth in a SCAP-independent manner. J Lipid Res. 2016 Aug;57(8):1564-73. [3]. Inoue K et al. Fatostatin, an SREBP inhibitor, prevented RANKL-induced bone loss by suppression of osteoclast differentiation. Biochim Biophys Acta. 2015 Nov;1852(11):2432-41. Chemical & Physical Properties Molecular Formula C18H18N2S Exact Mass 294.11900 PSA 54.02000 LogP 5.13300 InChIKey ZROSUBKIGBSZCG-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2934100090 |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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