![N,N-DIMETHYL-(3R,4AR,5S,6AS,10S,10AR,10BS)-5-(ACETYLOXY)-3-ETHENYLDODECAHYDRO-10,10B-DIHYDROXY-3,4A,7,7,10A-PENTAMETHYL-1-OXO-1H-NAPHTHO[2,1-B]PYRAN-6-YL ESTER B-ALANINE HYDROCHLORIDE structure, CAS 138605-00-2](/structures/210000/184982_1_138605_00_2.png)
CAS Number138605-00-2
Synonymscolforsindapropatehydrochloride; Adehl; NKH 477; colforsin daropate hydrochloride; 6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl; MKH 477
Molecular FormulaC27H44ClNO8
Molecular Weight546.09
Purity98.00%
Boiling Point571.4ºC at 760mmHg
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 138605-00-2 |
| Catalog No. | 2A-1183770 |
| Chinese Name | NKH 477(达福尔考辛) |
| Synonyms | colforsindapropatehydrochloride; Adehl; NKH 477; colforsin daropate hydrochloride; 6-[3-(dimethylamino)propionyl]-forskolin,Colforsin dapropate hydrochloride,N,N-dimethyl; MKH 477 |
| Molecular Formula | C27H44ClNO8 |
| Molecular Weight | 546.09 |
| Purity | 98.00 |
| Boiling Point | 571.4ºC at 760mmHg |
| Storage Condition | 2-8°C |
| Application | NKH477 (Colforsin dapropate hydrochloride) is a new water-soluble forskolin derivative that improves heart failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly |
| PubChem ID | 329818606 |
| MDL Number | MFCD00236421 |
| SMILES | C=CC1(C)CC(=O)C2(O)C(C)(O1)C(OC(C)=O)C(OC(=O)CCN(C)C)C1C(C)(C)CCC(O)C12C.Cl |
| InChI | InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1 |
| InChI Key | VIRRLEDAYYYTOD-YHEOSNBFSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | transportation |
| Bioactivity | NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Target Adenylate Cyclase[1] In Vivo NKH477 (Colforsin dapropate hydrochloride) (orally; 1-3 mg/kg/day; days 3 and 5) prolonged lung allograft survival in a dose dependent manner[1]. Animal Model: Specific-pathogen-free inbred male Lewis rats (LEW) weighing 250 to 280 g[1] Dosage: 1, 2 or 3 mg/kg/day Administration: Orally; daily; Days 3 and 5 Result: Prolonged lung allograft survival in a dose dependent manner. References [1]. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9. Chemical & Physical Properties Boiling Point 571.4ºC at 760mmHg Molecular Formula C27H44ClNO8 Molecular Weight 546.093 Flash Point 176ºC Exact Mass 545.275574 PSA 122.60000 LogP 2.82450 Vapour Pressure 5.29E-16mmHg at 25°C InChIKey VIRRLEDAYYYTOD-YHEOSNBFSA-N SMILES C=CC1(C)CC(=O)C2(O)C(C)(O1)C(OC(C)=O)C(OC(=O)CCN(C)C)C1C(C)(C)CCC(O)C12C.Cl Storage condition 2-8°C |
| Use of | NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. Properties Articles35 Name N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-ylesterβ-alaninehydrochloride Synonym More Synonyms NKH477 Biological Activity Description NKH477 (Colforsin dapropate hydrochloride) is a novel water-soluble forskolin derivative that improves cardiac failure mainly through its beneficial effects on diastolic cardiac function. NKH477 directly activates the catalytic unit of adenylate cyclase and increases intracellular cAMP. NKH477 exerts an antiproliferative effect in vivo with an altered cytokine profile to inhibit the acute rejection of rat orthotopic lung allografts[1]. Related Catalog Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Adenylate Cyclase Adenylate Cyclase[1] References [1]. Nakashima S, et al. Antiproliferative effects of NKH477, a forskolin derivative, on cytokine profile in rat lung allografts. J Heart Lung Transplant. 2005 Apr;24(4):462-9. Chemical & Physical Properties Exact Mass 545.275574 PSA 122.60000 LogP 2.82450 InChIKey VIRRLEDAYYYTOD-YHEOSNBFSA-N |
| Transport Info | Product name: Purity: 98.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European land transport hazard regulations: TOXIC SOLID, ORGANIC, N.O.S. (N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5- (acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5- (acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1) International air transport hazard regulations: Toxic solid, organic, n.o.s. (N,N-dimethyl-, (3R,4aR,5S,6S,6aS,10S,10aR,10bS)-5- (acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Dangerous Regulations for land transport: II International Dangerous Regulations for sea transport: II International Dangerous Regulations for air transport: II 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
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