CAS Number636-00-0
Synonyms5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide (1:1); 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1); 5-(2-aminoethyl)benzene-1,2,4-triol,hydrobromide; 5-(2-Aminoethyl)benzene-1,2,4-triol hydrobromide (1:1); EINECS 211-247-0; MFCD00012894; Oxidopamine (hydrobromide)
Molecular Formula(HO)3C6H2CH2CH2NH2 · HBr
Molecular Weight250.09
Boiling Point406ºC at 760 mmHg
Melting Point216-220 °C(lit.)
Appearancesolid | tan to brown
EINECS211-247-0
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 636-00-0 |
| Catalog No. | 2A-1183648 |
| Chinese Name | 6-羟基多巴胺氢溴酸盐 |
| Synonyms | 5-(2-Aminoethyl)-1,2,4-benzenetriol hydrobromide (1:1); 1,2,4-Benzenetriol, 5-(2-aminoethyl)-, hydrobromide (1:1); 5-(2-aminoethyl)benzene-1,2,4-triol,hydrobromide; 5-(2-Aminoethyl)benzene-1,2,4-triol hydrobromide (1:1); EINECS 211-247-0; MFCD00012894; Oxidopamine (hydrobromide) |
| Molecular Formula | (HO)3C6H2CH2CH2NH2 · HBr |
| Molecular Weight | 250.09 |
| Boiling Point | 406ºC at 760 mmHg |
| Melting Point | 216-220 °C(lit.) |
| Appearance | solid | tan to brown |
| Storage Condition | Store at room temperature and pressure. |
| Application | Oxidopamine hydrobromide is a selective catecholamine-containing neurotoxin that reduces brain catecholamine levels through absorption and accumulation through neuronal transmission mechanisms. |
| EINECS | 211-247-0 |
| HTC | 2922299090 |
| PubChem ID | 329751177 |
| MDL Number | MFCD00012894 |
| SMILES | Br.NCCc1cc(O)c(O)cc1O |
| InChI | InChI=1S/C8H11NO3.BrH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H |
| InChI Key | MLACDGUOKDOLGC-UHFFFAOYSA-N |
| Beilstein/REAXYS | 3713280 |
| NACRES Code | NA.77 |
| UNSPSC | 12352116 |
| Hazard Symbols | transportation |
| Bioactivity | Oxidopamine hydrobromide is a selective catecholaminergic neurotoxin, depletes brain catecholamine levels via uptake and accumulation by a transport mechanism specific to these neurons. In vitro: Oxidopamine hydrobromide-induced apoptosis of PC12 cells was initiated by superoxide generation followed by caspase cascade activation, which was associated with the suppressed Akt phosphorylation and increased p38 phosphorylation. It is likely that pCPT-cAMP prevented the Oxidopamine hydrobromide-induced apoptosis via activation of the PI3-kinase/Akt pathway without any effect on superoxide generation or mitochondrial membrane depolarization. [1]In vivo the presence of sulfhydryl antioxidants protected against neuronal degeneration in the striatum, which was particularly remarkable in the case of CySH and was attributed to its capacity to remove the H2O2 produced in the autoxidation of Oxidopamine hydrobromide. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Cancer References [1]. Fujita H et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23. [2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12. Chemical & Physical Properties Boiling Point 406ºC at 760 mmHg Melting Point 216-220 °C(lit.) Molecular Formula C8H12BrNO3 Molecular Weight 250.090 Flash Point 199.3ºC Exact Mass 249.000046 PSA 86.71000 LogP 1.96300 Appearance of Characters solid | tan to brown InChIKey MLACDGUOKDOLGC-UHFFFAOYSA-N SMILES Br.NCCc1cc(O)c(O)cc1O Storage condition 2-8°C |
| Use of | Properties Articles92 Name 6-Hydroxydopamine hydrobromide Synonym More Synonyms 6-HYDROXYDOPAMINE HYDROBROMIDE Biological Activity Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Cancer References [2]. Soto-Otero R et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12. Chemical & Physical Properties Molecular Formula C8H12BrNO3 Exact Mass 249.000046 PSA 86.71000 LogP 1.96300 Appearance of Characters solid | tan to brown InChIKey MLACDGUOKDOLGC-UHFFFAOYSA-N |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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