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Home > Products > Pharmaceuticals & Life Science > Pharmaceutical Intermediates > 6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline structure, CAS 356559-20-1

6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

CAS Number356559-20-1

Synonyms6-[2-tert-Butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl]quinoxaline; 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline; SB 525334; 6-[2-(2-Methyl-2-propanyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline; 6-(2-tert-butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl)quinoxaline; S1476_Selleck; SB525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; 6-[2-tert-butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline

Molecular FormulaC21H21N5

Molecular Weight343.42

Purity

Density1.2±0.1 g/cm3

Boiling Point540.5±45.0 °C at 760 mmHg

Melting Point159 °C

Flash Point

Appearanceyellow

EINECS

MSDSChineseEnglish

Symbol6.1

Signal WordWarning

Cat. No.: 2A-3183463 Purity:
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Quality Control of [ 356559-20-1 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number356559-20-1
Catalog No.2A-3183463
Chinese NameSB525334
Synonyms6-[2-tert-Butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl]quinoxaline; 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline; SB 525334; 6-[2-(2-Methyl-2-propanyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline; 6-(2-tert-butyl-4-(6-methylpyridin-2-yl)-1H-imidazol-5-yl)quinoxaline; S1476_Selleck; SB525334; 6-(2-(tert-Butyl)-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl)quinoxaline; 6-[2-tert-butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline
Molecular FormulaC21H21N5
Molecular Weight343.42
Density1.2±0.1 g/cm3
Boiling Point540.5±45.0 °C at 760 mmHg
Melting Point159 °C
Appearanceyellow
Water SolubilityDMSO: ≥20mg/mL
Storage Condition2-8°C
ApplicationSB 525334 is a potent and selective inhibitor of transforming growth factor beta 1 receptor (ALK5) with an IC50 of 14.3 nM.
HTC2934999090
PubChem ID329824610
MDL NumberMFCD11045307
SMILESCc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3nccnc3c2)n1
InChIInChI=1S/C21H21N5/c1-13-6-5-7-16(24-13)19-18(25-20(26-19)21(2,3)4)14-8-9-15-17(12-14)23-11-10-22-15/h5-12H,1-4H3,(H,25,26)
InChI KeyDKPQHFZUICCZHF-UHFFFAOYSA-N
NACRES CodeNA.77
UNSPSC12352200
Hazard Symbols6.1
BioactivitySB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM. Related Catalog Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor Research Areas >> Cancer References [1]. Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313(3), 943-951. [2]. Thomas M, et al. Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol, 2009, 174(2), 380-389. [3]. Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13(10), 3087-3899. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 540.5±45.0 °C at 760 mmHg Melting Point 159 °C Molecular Formula C21H21N5 Molecular Weight 343.425 Flash Point 238.6±21.7 °C Exact Mass 343.179688 PSA 67.35000 LogP 4.05 Appearance of Characters yellow Vapour Pressure 0.0±1.4 mmHg at 25°C Index of Refraction 1.636 InChIKey DKPQHFZUICCZHF-UHFFFAOYSA-N SMILES Cc1cccc(-c2[nH]c(C(C)(C)C)nc2-c2ccc3nccnc3c2)n1 Storage condition 2-8°C Water Solubility DMSO: ≥20mg/mL
Use ofSB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM. Properties Name 6-[2-tert-butyl-5-(6-methylpyridin-2-yl)-1H-imidazol-4-yl]quinoxaline Synonym More Synonyms SB525334 Biological Activity Description SB 525334 is a potent and selective transforming growth factor β1 receptor (ALK5) inhibitor with an IC50 of 14.3 nM. Related Catalog Signaling Pathways >> TGF-beta/Smad >> TGF-β Receptor Research Areas >> Cancer References [1]. Grygielko ET, et al. Inhibition of gene markers of fibrosis with a novel inhibitor of transforming growth factor-beta type I receptor kinase in puromycin-induced nephritis. J Pharmacol Exp Ther, 2005, 313(3), 943-951. [2]. Thomas M, et al. Activin-like kinase 5 (ALK5) mediates abnormal proliferation of vascular smooth muscle cells from patients with familial pulmonary arterial hypertension and is involved in the progression of experimental pulmonary arterial hypertension induced by monocrotaline. Am J Pathol, 2009, 174(2), 380-389. [3]. Laping NJ, et al. Tumor-specific efficacy of transforming growth factor-beta RI inhibition in Eker rats. Clin Cancer Res, 2007, 13(10), 3087-3899. Chemical & Physical Properties Molecular Formula C21H21N5 Exact Mass 343.179688 PSA 67.35000 Appearance of Characters yellow Index of Refraction 1.636 InChIKey DKPQHFZUICCZHF-UHFFFAOYSA-N
Tax Rebate13.0%
SupervisionNone. MFN tariff: 6.5%. Ordinary tariff: 20.0%
Transport InfoProduct name: Purity: 98.0%
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (SB-525334) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (SB-525334) International air transport hazard regulations: Toxic solid, organic, n.o.s. (SB-525334) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available See reverse side of invoice or packing slip.
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