CAS Number132489-69-1
Synonyms(Z)-Pugnac,O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate; O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
Molecular FormulaC36H39NO6
Molecular Weight581.715
Purity98.00%
Density1.53g/cm3
Melting Point172-175°C
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 132489-69-1 |
| Catalog No. | 2A-1182873 |
| Chinese Name | O-(2-乙酰氨基-2-脱氧-D-吡喃葡萄糖亚基)氨基酸 N-苯氨基甲酸甲酯 |
| Synonyms | (Z)-Pugnac,O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate; O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate |
| Molecular Formula | C36H39NO6 |
| Molecular Weight | 581.715 |
| Purity | 98.00 |
| Density | 1.53g/cm3 |
| Melting Point | 172-175°C |
| Storage Condition | -20℃ |
| Application | (Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a more potent O-GlcNAcase inhibitor than E-type [1]. |
| PubChem ID | 17137224 |
| MDL Number | MFCD02685298 |
| SMILES | CC(=O)NC1C(=NOC(=O)Nc2ccccc2)OC(CO)C(O)C1O |
| InChI | InChI=1S/C15H19N3O7/c1-8(20)16-11-13(22)12(21)10(7-19)24-14(11)18-25-15(23)17-9-5-3-2-4-6-9/h2-6,10-13,19,21-22H,7H2,1H3,(H,16,20)(H,17,23)/b18-14-/t10-,11-,12-,13-/m1/s1 |
| InChI Key | PBLNJFVQMUMOJY-JXZOILRNSA-N |
| Hazard Symbols | transportation |
| Bioactivity | (Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro (Z)-PUGNAc amplifies the incorporation of O-GlcNAc on proteins within both HeLa and HEK cell systems[1]. References [1]. Perreira M, et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem. 2006;14(3):837-846. Chemical & Physical Properties Density 1.53g/cm3 Melting Point 172-175°C Molecular Formula C15H19N3O7 Molecular Weight 353.33 Exact Mass 353.12200 PSA 149.71000 Index of Refraction 1.638 InChIKey PBLNJFVQMUMOJY-JXZOILRNSA-N SMILES CC(=O)NC1C(=NOC(=O)Nc2ccccc2)OC(CO)C(O)C1O Storage condition -20℃ |
| Use of | (Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form[1]. Properties Articles53 Name O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-Phenylcarbamate Synonym More Synonyms PugNAc Biological Activity Description (Z)-PUGNAc is a potent O-GlcNAcase inhibitor. (Z)-PUGNAc is a vastly more potent inhibitor of O-GlcNAcase than the E form[1]. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Metabolic Disease In Vitro (Z)-PUGNAc amplifies the incorporation of O-GlcNAc on proteins within both HeLa and HEK cell systems[1]. References [1]. Perreira M, et al. Inhibition of O-GlcNAcase by PUGNAc is dependent upon the oxime stereochemistry. Bioorg Med Chem. 2006;14(3):837-846. Chemical & Physical Properties Molecular Formula C15H19N3O7 Exact Mass 353.12200 PSA 149.71000 Index of Refraction 1.638 InChIKey PBLNJFVQMUMOJY-JXZOILRNSA-N Storage condition -20℃ |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
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