CAS Number96206-92-7
Synonyms2-Methyl-6-(phenylethynyl)pyridine hydrochloride; MPEP,HCl; MFCD02262119; Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1); MPEP; 2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1); 2-methyl-6-phenylethynyl-pyridine; 2-Methyl-6-phenylaethinyl-pyridin
Molecular FormulaC14H11N
Molecular Weight229.70
Boiling Point336.3ºC at 760mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 96206-92-7 |
| Catalog No. | 2A-2182248 |
| Chinese Name | 2-甲基-6-(苯基乙炔基)吡啶 |
| Synonyms | 2-Methyl-6-(phenylethynyl)pyridine hydrochloride; MPEP,HCl; MFCD02262119; Pyridine, 2-methyl-6-(2-phenylethynyl)-, hydrochloride (1:1); MPEP; 2-Methyl-6-(phenylethynyl)pyridine hydrochloride (1:1); 2-methyl-6-phenylethynyl-pyridine; 2-Methyl-6-phenylaethinyl-pyridin |
| Molecular Formula | C14H11N |
| Molecular Weight | 229.70 |
| Boiling Point | 336.3ºC at 760mmHg |
| Storage Condition | Desiccate at +4°C |
| Application | MPEP is a non-competitive antagonist of mGlu5 receptors with an IC50 of 36 nM and a positive allosteric modulator of mGlu4 receptors. |
| HTC | 2933399090 |
| PubChem ID | 24278557 |
| MDL Number | MFCD02262119 |
| SMILES | Cc1cccc(C#Cc2ccccc2)n1 |
| InChI | InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3 |
| InChI Key | NEWKHUASLBMWRE-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Use of | Properties Name MPEP hydrochloride,2-Methyl-6-(phenylethynyl)pyridinehydrochloride Synonym More Synonyms MPEP Biological Activity Related Catalog Research Areas >> Neurological Disease References [1]. D'Souza, Manoranjan S.; Markou, Athina Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. [2]. Chau, Peipei; Soederpalm, Bo; Ericson, Mia The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. Addiction Biology (2011), 16(4), 591-599. [3]. Inta, Dragos; Filipovic, Dragana; Lima-Ojeda, Juan M. et al. The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: Significance for the use as anxiolytic/ant Chemical & Physical Properties Molecular Formula C14H11N PSA 12.89000 LogP 3.59180 InChIKey NEWKHUASLBMWRE-UHFFFAOYSA-N Safety Information HS Code 2933399090 Synthetic Route 2-Bromo-6-methy... CAS#:5315-25-3 trimethylsilyle... CAS#:2170-06-1 CAS#:96206-92-7 Literature: Sorensen, Ulrik S.; Pombo-Villar, Esteban Tetrahedron, 2005 , vol. 61, # 10 p. 2697 - 2703 2-Bromo-6-methy... CAS#:5315-25-3 Phenylacetylene CAS#:536-74-3 CAS#:96206-92-7 Literature: Saleh, Samer; Picquet, Michel; Meunier, Philippe; Hierso, Jean-Cyrille Synlett, 2011 , # 19 art. no. D22511ST, p. 2844 - 2848 2-Bromo-6-methy... CAS#:5315-25-3 3-Phenylpropiol... CAS#:637-44-5 CAS#:96206-92-7 Literature: Reddy, Police Vishnuvardhan; Srinivas, Pottabathula; Annapurna, Manne; Bhargava, Suresh; Wagler, Jorg; Mirzadeh, Nedaossadat; Kantam, Mannepalli Lakshmi Advanced Synthesis and Catalysis, 2013 , vol. 355, # 4 p. 705 - 710 Precursor & DownStream Precursor 7 CAS#:5315-25-3 2-Bromo-6-methy... CAS#:2170-06-1 trimethylsilyle... CAS#:536-74-3 Phenylacetylene CAS#:637-44-5 3-Phenylpropiol... DownStream 1 CAS#:1083-25-6 Ethanone,2-(6-m... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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