| Chemical & Physical Properties | |
|---|---|
| CAS Number | 108852-90-0 |
| Catalog No. | 2A-2182207 |
| Chinese Name | 奈莫柔比星 |
| Synonyms | Nemorubicin; Nemorubicin [INN]; methoxy-morpholynil-doxorubicin |
| Molecular Formula | C32H37O13N1 |
| Molecular Weight | 643.64 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 852.2±65.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | emorubicin is a doxorubicin derivative with antitumor activity. |
| HTC | 2933990090 |
| PubChem ID | 8190026 |
| MDL Number | MFCD00871079 |
| SMILES | COc1cccc2c1C(=O)c1c(O)c3c(c(O)c1C2=O)CC(O)(C(=O)CO)CC3OC1CC(N2CCOC(OC)C2)C(O)C(C)O1 |
| InChI | InChI=1S/C32H37NO13/c1-14-27(36)17(33-7-8-44-22(12-33)43-3)9-21(45-14)46-19-11-32(41,20(35)13-34)10-16-24(19)31(40)26-25(29(16)38)28(37)15-5-4-6-18(42-2)23(15)30(26)39/h4-6,14,17,19,21-22,27,34,36,38,40-41H,7-13H2,1-3H3/t14-,17-,19-,21-,22-,27+,32-/m0/s1 |
| InChI Key | CTMCWCONSULRHO-UHQPFXKFSA-N |
| Use of | Nemorubicin is a derivative of doxorubicin, and has antitumor activity. Properties Name nemorubicin Synonym More Synonyms Nemorubicin Biological Activity Description Nemorubicin is a derivative of doxorubicin, and has antitumor activity. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Cancer References [1]. Quintieri L, et al. Formation and antitumor activity of PNU-159682, a major metabolite of nemorubicin in human liver microsomes. Clin Cancer Res. 2005 Feb 15;11(4):1608-17. [2]. Quintieri L, et al. In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: a comparison with human liver microsomes. Biochem Pharmacol. 2008 Sep 15;76(6):784-95. [3]. Sabatino MA, et al. Down-regulation of the nucleotide excision repair gene XPG as a new mechanism of drug resistance in human and murine cancer cells. Mol Cancer. 2010 Sep 24;9:259. Chemical & Physical Properties Molecular Formula C32H37NO13 Exact Mass 643.226501 PSA 201.75000 Index of Refraction 1.681 InChIKey CTMCWCONSULRHO-UHQPFXKFSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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