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OLPRINONE HYDROCHLORIDE structure, CAS 119615-63-3

OLPRINONE HYDROCHLORIDE

CAS Number119615-63-3

SynonymsE 1020; pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride; Olprinone hydrochloride; Olprinone (Hydrochloride); 1,2-dihydro-5-imidazo<1,2-a>pyridin-6-yl-6-methyl-2-oxo-3-pyridine carbonitrile hydrochloride; 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride; MFCD01749474; Loprinone hydrochloride

Molecular FormulaC14H11ClN4O

Molecular Weight286.72

Purity

Density1.34g/cm3

Boiling Point

Melting Point>300ºC

Flash Point

Appearance

EINECS

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Cat. No.: 2A-2182098 Purity:
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Quality Control of [ 119615-63-3 ] SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number119615-63-3
Catalog No.2A-2182098
Chinese NameOlprinone Hydrochloride
SynonymsE 1020; pyridin-6-yl-6-methyl-2-oxo-3-pyridinecarbonitrile hydrochloride; Olprinone hydrochloride; Olprinone (Hydrochloride); 1,2-dihydro-5-imidazo<1,2-a>pyridin-6-yl-6-methyl-2-oxo-3-pyridine carbonitrile hydrochloride; 1,2-dihydro-6-methyl-2-oxo-5-(imidazo[1,2-a]pyridin-6-yl)-3-pyridine carbonitrile hydrochloride; MFCD01749474; Loprinone hydrochloride
Molecular FormulaC14H11ClN4O
Molecular Weight286.72
Density1.34g/cm3
Melting Point>300ºC
Storage Condition2-8℃
ApplicationOlprinone (Loprinone) hydrochloride is a phosphodiesterase 3 (PDE3) inhibitor.
PubChem ID853911
SMILESCc1[nH]c(=O)c(C#N)cc1-c1ccc2nccn2c1.Cl
InChIInChI=1S/C14H10N4O.ClH/c1-9-12(6-11(7-15)14(19)17-9)10-2-3-13-16-4-5-18(13)8-10;/h2-6,8H,1H3,(H,17,19);1H
InChI KeyPWTBMBAQRAOAFF-UHFFFAOYSA-N
Hazard Symbolstransportation
BioactivityOlprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease References [1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 . [2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22. [3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83. [4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79. Chemical & Physical Properties Density 1.34g/cm3 Melting Point >300ºC Molecular Formula C14H11ClN4O Molecular Weight 286.72 PSA 83.18000 LogP 2.60738 InChIKey PWTBMBAQRAOAFF-UHFFFAOYSA-N SMILES Cc1[nH]c(=O)c(C#N)cc1-c1ccc2nccn2c1.Cl Storage condition 2-8℃
Use ofOlprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. Properties Articles25 Name 5-imidazo[1,2-a]pyridin-6-yl-6-methyl-2-oxo-1H-pyridine-3-carbonitrile,hydrochloride Synonym More Synonyms Olprinone (Hydrochloride) Biological Activity Description Olprinone Hcl(Loprinone Hcl) is a selective phosphodiesterase 3 (PDE3) inhibitor. IC50 value:Target: PDE3Olprinone is used as cardiotonic agent with positive inotropic and vasodilating effects. Olprinone has been reported to improve microcirculation and attenuate inflammation. Olprinone is often used to increase cardiac output after cardiopulmonary bypass (CPB). Olprinone was infused at a rate of 0.2 μg/kg/min when weaning from CPB was started. Olprinone has also shown potent antioxidative and anti-inflammatory effects in the meconium-induced oxidative lung injury. Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphodiesterase (PDE) Research Areas >> Cardiovascular Disease References [1]. Tsubokawa T, Ishizuka S, Fukumoto K, et al. The effect of hemodilution by cardiopulmonary bypass on protein binding of olprinone. J Anesth. 2012 . [2]. Mokra D, Drgova A, Pullmann R Sr, et al. Selective phosphodiesterase 3 inhibitor olprinone attenuates meconium-induced oxidative lung injury. Pulm Pharmacol Ther. 2012 Jun;25(3):216-22. [3]. Yamanaka H, Hayashi Y, Kamibayashi T, Mashimo T. Effect of olprinone, a phosphodiesterase III inhibitor, on balance of cerebral oxygen supply and demand during cardiopulmonary bypass. J Cardiovasc Pharmacol. 2011 May;57(5):579-83. [4]. Mazzon E, Esposito E, Di Paola R, et al. Olprinone, a specific phosphodiesterase (PDE)-III inhibitor, reduces the development of multiple organ dysfunction syndrome in mice. Pharmacol Res. 2011 Jul;64(1):68-79. Chemical & Physical Properties PSA 83.18000 LogP 2.60738 InChIKey PWTBMBAQRAOAFF-UHFFFAOYSA-N Storage condition 2-8℃
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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