CAS Number102-60-3
SynonymsEdetol; 1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-ol; 1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol); 1,1',1'',1'''-(Ethylenedinitrilo)-tetra-2-propanol; N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine; Quadrol; N,N,N'N'-tetra(2-hydropropyl)ethylene diamine; THPE; 1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol; Entprol; EINECS 203-041-4; 1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetra(2-propanol); MFCD00004534; 1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetrakis[2-propanol]; Ethylenediamine-N,N,N',N'-tetra-2-propanol; EDTP
Molecular Formula[CH3CH(OH)CH2]2NCH2CH2N[CH2CH(OH)CH3]2
Molecular Weight292.41
Purity98%
Density1.1±0.1 g/cm3
Boiling Point175-181 °C/0.8 mmHg (lit.)
Melting Point32°C
AppearanceTransparent colorless-light yellow
EINECS203-041-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 102-60-3 |
| Catalog No. | 2A-9018308 |
| Chinese Name | 四羟丙基乙二胺 |
| Synonyms | Edetol; 1,1',1'',1'''-(Ethane-1,2-diyldinitrilo)tetrapropan-2-ol; 1,1',1'',1'''-(Ethane-1,2-diylbis(azanetriyl))tetrakis(propan-2-ol); 1,1',1'',1'''-(Ethylenedinitrilo)-tetra-2-propanol; N,N,N',N'-Tetrakis(2-hydroxypropyl)ethylenediamine; Quadrol; N,N,N'N'-tetra(2-hydropropyl)ethylene diamine; THPE; 1,1',1'',1'''-(ethylenedinitrilo)tetra-2-propanol; Entprol; EINECS 203-041-4; 1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetra(2-propanol); MFCD00004534; 1,1',1'',1'''-(1,2-Ethanediyldinitrilo)tetrakis[2-propanol]; Ethylenediamine-N,N,N',N'-tetra-2-propanol; EDTP |
| Molecular Formula | [CH3CH(OH)CH2]2NCH2CH2N[CH2CH(OH)CH3]2 |
| Molecular Weight | 292.41 |
| Purity | 98 |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 175-181 °C/0.8 mmHg (lit.) |
| Melting Point | 32°C |
| Appearance | Transparent colorless-light yellow |
| Water Solubility | miscible |
| Storage Condition | Store in a cool, ventilated warehouse. Keep away f |
| Application | Quadrol is an immunostimulant that has been considered a potentially useful drug for accelerating wound healing. |
| EINECS | 203-041-4 |
| HTC | 29221980 |
| PubChem ID | 24847480 |
| MDL Number | MFCD00004534 |
| SMILES | CC(O)CN(CCN(CC(C)O)CC(C)O)CC(C)O |
| InChI | 1S/C14H32N2O4/c1-11(17)7-15(8-12(2)18)5-6-16(9-13(3)19)10-14(4)20/h11-14,17-20H,5-10H2,1-4H3 |
| InChI Key | NSOXQYCFHDMMGV-UHFFFAOYSA-N |
| Beilstein/REAXYS | 1781143 |
| NACRES Code | NA.23 |
| UNSPSC | 12162002 |
| Hazard Symbols | Transport |
| MSDS | msds/18308_1_102_60_3.pdf |
| Bioactivity | Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vitro Results show that viability of macrophages incubated with Quadrol at concentrations of 0.5 mM, 1 mM and 4mM are identical to that for controls. Viability, however, is reduced to 50% of control at concentrations of 16 mM to 32 mM. After four hours, at concentrations of 1 mM and 4 mM, Quadrol produces enhanced spreading of 88% and 80%, respectively, as compared to the control of 28%. Quadrol, at a concentration of 16 mM, shows reduced percentage of spreading of macrophages after four hours. Exposure of macrophages to 1.0 mM or 4.0 mM Quadrol concentrations enhances phagocytic activity, 41% and 57%, respectively, over that of the cells exposed to media alone (34%)[1]. In Vivo On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5)[2]. Cell Assay The standard trypan blue exclusion test is performed to measure cell viability (10). Cells are exposed to increasing concentrations of Quadrol (0.5 mM to 32 mM) and incubated at 37°C for varying lengths of time before treatment with trypan blue[1]. Animal Admin At the time of polytetrafluoroethylene (PTFE) tubing implantation, six test groups (3 streptozotocin-induced (STZ) diabetic and 3 non-diabetic) consisting of 5 to 7 animals per sampling time receive either diluent (control group) or Quadrol (10 mM) injected approximately 1 cm from the implantation site. The PTFE implants recovered from the mice after 2 to 14 days are stored frozen until processed and then analyzed by the HPLC method[2]. References [1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12. [2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22. Chemical & Physical Properties Density 1.1±0.1 g/cm3 Boiling Point 369.1±0.0 °C at 760 mmHg Melting Point 32°C Molecular Formula C14H32N2O4 Molecular Weight 292.415 Flash Point 145.7±17.4 °C Exact Mass 292.236206 PSA 87.40000 LogP 0.13 Vapour Pressure 0.0±1.8 mmHg at 25°C Index of Refraction 1.517 InChIKey NSOXQYCFHDMMGV-UHFFFAOYSA-N SMILES CC(O)CN(CCN(CC(C)O)CC(C)O)CC(C)O Water Solubility miscible |
| Use of | Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing. Properties Articles13 Name N,N,N,N-Tetrakis(2-Hydroxypropyl)- Ethylenediamine Synonym More Synonyms Edetol Biological Activity Description Quadrol is an immunostimulant and has been implicated as a potentially useful agent in accelerated wound healing. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Inflammation/Immunology In Vivo On day eight after the implantation, the amount of collagen in the implants of normal mice injected with Quadrol exceeds controls by more than 200% (p<0.025). By day 11, the collagen content increases to over 300% higher than controls (p<0.01) and by the end of two weeks after wounding, the time interval typically required for normal and complete wound healing, the collagen accumulated in the implants of the Quadrol-treated mice is about 50% above control (p<0.1). The accumulation of collagen in the implants of Quadrol treated STZ-diabetic mice about 100% above the untreated diabetic control on days 8 to 11. By day 14, the collagen deposition has increased to 200% above the controls (p<0.0 5)[2]. References [1]. Bhide MV, et al. In vitro stimulation of macrophages by quadrol [N,N,N',N'-tetrakis(2-hydroxypropyl)ethylenediamine]. J Immunopharmacol. 1985;7(3):303-12. [2]. Bhide MV, et al. Promotion of wound collagen formation in normal and diabetic mice by quadrol. Immunopharmacol Immunotoxicol. 1988;10(4):513-22. Chemical & Physical Properties Molecular Formula C14H32N2O4 Exact Mass 292.236206 PSA 87.40000 Index of Refraction 1.517 InChIKey NSOXQYCFHDMMGV-UHFFFAOYSA-N SMILES CC(O)CN(CCN(CC(C)O)CC(C)O)CC(C)O Water Solubility miscible |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 United Nations number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special precautions No data available |
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