| Chemical & Physical Properties | |
|---|---|
| CAS Number | 27367-90-4 |
| Catalog No. | 2A-1181849 |
| Chinese Name | 尼普拉嗪 |
| Synonyms | Nopron; EINECS 248-431-5; Niaprazine |
| Molecular Formula | C20H25O1N4F1 |
| Molecular Weight | 356.44 |
| Purity | 98.00 |
| Appearance | solid |
| Storage Condition | Room temperature, sealed, dry |
| Application | Niaprazine is a potent sedative histamine H1-receptor antagonist. Niaprazine has antihistamine and antiserotonin activity and has been used in the study of sleep disorders. |
| HTC | 2933599090 |
| PubChem ID | 8194908 |
| MDL Number | MFCD00867991 |
| SMILES | CC(CCN1CCN(c2ccc(F)cc2)CC1)NC(=O)c1cccnc1 |
| InChI | InChI=1S/C20H25FN4O.3ClH/c1-16(23-20(26)17-3-2-9-22-15-17)8-10-24-11-13-25(14-12-24)19-6-4-18(21)5-7-19;;;/h2-7,9,15-16H,8,10-14H2,1H3,(H,23,26);3*1H |
| InChI Key | RSKQGBFMNPDPLR-UHFFFAOYSA-N |
| Use of | Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2]. Properties Name N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-yl]pyridine-3-carboxamide Synonym More Synonyms Niaprazine Biological Activity Description Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2]. Related Catalog Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Histamine Receptor In Vitro Niaprazine exhibits a low affinity for the vesicular monoamine transporter and for D2, α2, β, H1 and mAch receptors. Niaprazine, particularly the (+)stereoisomer, has a higher affinity for α1 (Ki = 77 nM) and 5-HT2 (Ki = 25 nM) binding sites, but is poorly recognized by 5-HT1A and 5-HT1B binding sites[2]. References [1]. D Scherman, et al. Molecular pharmacology of niaprazine. Prog Neuropsychopharmacol Biol Psychiatry. 1988;12(6):989-1001. [2]. P G Rossi, et al. Niaprazine in the treatment of autistic disorder. J Child Neurol. 1999 Aug;14(8):547-50. [3]. P E Keane, et al. The effect of niaprazine on the turnover of 5-hydroxytryptamine in the rat brain. Neuropharmacology. 1982 Feb;21(2):163-9. Chemical & Physical Properties Molecular Formula C20H25FN4O Exact Mass 356.20100 PSA 51.96000 LogP 3.12900 InChIKey RSKQGBFMNPDPLR-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Nicotinamide, N-(3-(4-(p-fluorophenyl)-1-piperazinyl)-1-methylpropy l)- CAS REGISTRY NUMBER : 27367-90-4 BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C20-H25-F-N4-O MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #1957371 TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : GWXXBX German Offenlegungsschrift Patent Document. (U.S. Patent and Trademark Office, Foreign Patents, Washington, DC 20231) Volume(issue)/page/year: #1957371 Safety Information Hazard Codes Xi HS Code 2933599090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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