CAS Number133550-35-3
SynonymsTyrphostin 48; HMS3266B19; (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide; AG-494
Molecular FormulaC16H12N2O3
Molecular Weight280.278
Density1.4±0.1 g/cm3
Boiling Point586.9±50.0 °C at 760 mmHg
Melting Point249 °C(dec.)
AppearanceSolid;Light yellow to Amber to Dark green powder to crystal
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 133550-35-3 |
| Catalog No. | 2A-2181405 |
| Chinese Name | AG-494 |
| Synonyms | Tyrphostin 48; HMS3266B19; (2E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-phenylacrylamide; AG-494 |
| Molecular Formula | C16H12N2O3 |
| Molecular Weight | 280.278 |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 586.9±50.0 °C at 760 mmHg |
| Melting Point | 249 °C(dec.) |
| Appearance | Solid;Light yellow to Amber to Dark green powder to crystal |
| Storage Condition | 0-10°C; avoid light, heat |
| Application | AG-494 (Tyrphostin AG 494) is a highly potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50 of 1.1, 39 |
| PubChem ID | 8033981 |
| SMILES | N#CC(=Cc1ccc(O)c(O)c1)C(=O)Nc1ccccc1 |
| InChI | InChI=1S/C16H12N2O3/c17-10-12(8-11-6-7-14(19)15(20)9-11)16(21)18-13-4-2-1-3-5-13/h1-9,19-20H,(H,18,21)/b12-8+ |
| InChI Key | HKHOVJYOELRGMV-XYOKQWHBSA-N |
| Transport Info | Product name: Tyrosine kinase inhibitor AG 494 |
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