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BETA-ELEMENE 82%

Name: BETA-ELEMENE 82%
Brand: 2A Biotech
SKU: 2A-9018217

CAS Number515-13-9

Synonyms(5S,7R,10S)-(-)-1-methyl-1-vinyl-2,4-diisopropenyl-cyclohexane; (1S,2S,4R)-1-methyl-1-vinyl-2,4-diisopropenylcyclohexane; C15 H24,Cyclohexan,1-ethenyl-1-methyl-2,4-bis(1-methylethenyl); (1S,2S,4R)-1-Ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane

Molecular FormulaC15H24

Molecular Weight204.35

Purity≥98.0 (GC)%

Density0.862g/cm3

Boiling Point252.1ºC at 760mmHg

MSDSChinese English

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Cat. No.: 2A-9018217 Purity: ≥98.0 (GC)%

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Quality Control of [ 515-13-9 ] Purity: ≥98.0 (GC)% SDS Specification MoL

Chemical & Physical Properties
CAS Number	515-13-9
Catalog No.	2A-9018217
Chinese Name	β-榄香烯
Synonyms	(5S,7R,10S)-(-)-1-methyl-1-vinyl-2,4-diisopropenyl-cyclohexane; (1S,2S,4R)-1-methyl-1-vinyl-2,4-diisopropenylcyclohexane; C15 H24,Cyclohexan,1-ethenyl-1-methyl-2,4-bis(1-methylethenyl); (1S,2S,4R)-1-Ethenyl-1-methyl-2,4-bis(1-methylethenyl)cyclohexane
Molecular Formula	C15H24
Molecular Weight	204.35
Purity	≥98.0 (GC)
Density	0.862g/cm3
Boiling Point	252.1ºC at 760mmHg
Storage Condition	2-8°C
Application	β-Elemene ((-)-β-Elemene; Levo-β-elemene) is extracted from the natural plant turmeric (Curcuma wenyujin) and has anti-tumor activity. β-Elemene ((-)-β-Elemene; Levo-β-elemene; β-Elemen) can induce ap
HTC	2902199090
PubChem ID	329759915
MDL Number	MFCD00468041
SMILES	C[C@@]1(C=C)CC[C@@H](C(C)=C)C[C@H]1C(C)=C
InChI	1S/C15H24/c1-7-15(6)9-8-13(11(2)3)10-14(15)12(4)5/h7,13-14H,1-2,4,8-10H2,3,5-6H3/t13-,14+,15-/m1/s1
InChI Key	OPFTUNCRGUEPRZ-QLFBSQMISA-N
Beilstein/REAXYS	2207781
NACRES Code	NA.24
UNSPSC	85151701
Hazard Symbols	Transport
MSDS	msds/18217_1_515_13_9.pdf
Bioactivity	β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer In Vitro β-Elemene (0-200 µg/ml; 24 hours) shows IC50 values of 72.8 µg/ml; 47.4 µg/ml; 61.5 µg/ml; 3.661 µg/ml; 68 µg/ml; 72.12 µg/ml; 37.894 µg/ml and 37.703 µg/ml for SV-HUC-1, T24, 5637, TCCSUP, J82,UMUC-3,RT4, and SW780 cells, respectively[1]. β-Elemene (0-75 µg/ml; 24 hours) decreases cell number from 50 µg/ml and is notably decreased at 75 µg/ml, induces dose-dependent G1-phase arrest in T24cells and significantly reduces the percentage of cells in the S-phase [1]. β-Elemene (50 µg/ml; 12 hours) downregulates the expression levels of p-STAT3 and the cell cycle-related proteins cyclin D1, CDK4 and CDK6, and upregulates p21 and p27expression in T24 cells [1]. β-Elemene (50 µg/ml; 24 hours) enhances cisplatin-induced apoptosis by activating the ROS-AMPK signaling pathway[1]. Cell Viability Assay[2] Cell Line: T24, 5637, TCCSUP, J82, UM-UC-3, RT4 and SW780 cells Concentration: 0, 6.25, 12.5, 25, 50, 100, 150 and 200 µg/ml Incubation Time: 24 hours Result: Inhibited the proliferation of RT4, SW780, J82, UMUC-3, TCCSUP, 5637 and T24 human bladder cancer cells and SV-HUC-1 human urothelial cells. Cell Cycle Analysis[2] Cell Line: T24 and 5637 cells Concentration: 0, 25, 50 and 75 µg/ml Incubation Time: 24 hours Result: Induced the percentage of cells in the S-phase as a dose-dependent manner. Western Blot Analysis[2] Cell Line: T24 cells Concentration: 50 µg/ml Incubation Time: 24 hours Result: Downregulated p-STAT3 and cell cycle-related proteins. References [1]. Ross, S.A., and ElSohly, M.A. The volatile oil composition of fresh and air-dried buds of Cannabis sativa. J. Nat. Prod. 59(1), 49-51 (1996). [2]. Gan D, et al. β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway.Oncol Lett. 2020 Jan;19(1):291-300. Chemical & Physical Properties Density 0.862g/cm3 Boiling Point 252.1ºC at 760mmHg Molecular Formula C15H24 Molecular Weight 204.35100 Flash Point 98.3ºC Exact Mass 204.18800 LogP 4.74720 Index of Refraction 1.501 Storage condition 2-8°C
Use of	β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis. Properties Name β-ELEMENE 82% Synonym More Synonyms beta-elemene Biological Activity Description β-Elemene ((-)-β-Elemene; Levo-β-elemene) is isolated from natural plant Curcuma wenyujin with an antitumor activity. β-Elemene can induce cell apoptosis. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer References [1]. Ross, S.A., and ElSohly, M.A. The volatile oil composition of fresh and air-dried buds of Cannabis sativa. J. Nat. Prod. 59(1), 49-51 (1996). [2]. Gan D, et al. β-elemene enhances cisplatin-induced apoptosis in bladder cancer cells through the ROS-AMPK signaling pathway.Oncol Lett. 2020 Jan;19(1):291-300. Chemical & Physical Properties Molecular Formula C15H24 Exact Mass 204.18800 LogP 4.74720 Index of Refraction 1.501
Tax Rebate	9.0%
Supervision	none
Transport Info	Shipping Name: UN
MSDS Transport Info	Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available

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BETA-ELEMENE 82%

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