CAS Number2199-87-3
Synonyms6-bromo-2-oxo-2H-1-benzopyran-3-carboxylic acid; 6-Bromochromon-3-carboxylic acid; 6-Bromo-2-oxo-2H-chromene-3-carboxylic acid 6-Bromo-3-carboxycoumarin; 6-bromo-2-oxo-2Hchromene-3-carboxylic acid; MFCD00047640; 6-Bromocoumarin-3-carboxylic acid; 6-Bromocoumarin-3-carboxylicAcid
Molecular FormulaC10H5BrO4
Molecular Weight138.12
Density1.874g/cm3
Boiling Point439ºC at 760mmHg
Melting Point195-198 °C(lit.)
EINECS221-630-4
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 2199-87-3 |
| Catalog No. | 2A-2180493 |
| Chinese Name | 6-溴香豆素-3-甲酸 |
| Synonyms | 6-bromo-2-oxo-2H-1-benzopyran-3-carboxylic acid; 6-Bromochromon-3-carboxylic acid; 6-Bromo-2-oxo-2H-chromene-3-carboxylic acid 6-Bromo-3-carboxycoumarin; 6-bromo-2-oxo-2Hchromene-3-carboxylic acid; MFCD00047640; 6-Bromocoumarin-3-carboxylic acid; 6-Bromocoumarin-3-carboxylicAcid |
| Molecular Formula | C10H5BrO4 |
| Molecular Weight | 138.12 |
| Density | 1.874g/cm3 |
| Boiling Point | 439ºC at 760mmHg |
| Melting Point | 195-198 °C(lit.) |
| Storage Condition | The storage place must be away from oxidants, keep |
| Application | UBP608 is a potent negative allosteric modulator of N-methyl-D-aspartate receptors (NMDARs). UBP608 has the potential to study neurological diseases [1]. |
| EINECS | 221-630-4 |
| HTC | 2932209090 |
| PubChem ID | 24852983 |
| MDL Number | MFCD00006326 |
| SMILES | O=C(O)c1cc2cc(Br)ccc2oc1=O |
| InChI | InChI=1S/C10H5BrO4/c11-6-1-2-8-5(3-6)4-7(9(12)13)10(14)15-8/h1-4H,(H,12,13)/p-1 |
| InChI Key | XFQHPAXNKDYMOX-UHFFFAOYSA-N |
| Beilstein/REAXYS | 115992 |
| NACRES Code | NA.22 |
| UNSPSC | 12352100 |
| Hazard Symbols | transportation |
| Bioactivity | UBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Target NMDA Receptor In Vitro UBP608 (100 µM) showed inhibitory activity with inhibition rates of 89.3%, 63.5%, 56.1%, and 23.6% against GluN1/GluN2A, GluN1/GluN2B, GluN1/GluN2C, and GluN1/GluN2D respectively [1]. References [1]. Irvine MW, et al. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int. 2012 Sep;61(4):593-600. Chemical & Physical Properties Density 1.874g/cm3 Boiling Point 439ºC at 760mmHg Melting Point 195-198 °C(lit.) Molecular Formula C10H5BrO4 Molecular Weight 269.04800 Flash Point 219.3ºC Exact Mass 267.93700 PSA 67.51000 LogP 2.25370 Vapor Pressure 1.76E-08mmHg at 25°C InChIKey XFQHPAXNKDYMOX-UHFFFAOYSA-N SMILES O=C(O)c1cc2cc(Br)ccc2oc1=O Storage condition room temp |
| Use of | UBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders[1]. Properties Name 6-bromo-2-oxochromene-3-carboxylic acid Synonym More Synonyms 6-bromocoumarin-3-carboxylic acid Biological Activity Description UBP608 is a potent N-Methyl-D-aspartate receptors (NMDARs) negative allosteric modulator. UBP608 has the potential for the research of neurological disorders[1]. Related Catalog Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR NMDA Receptor References [1]. Irvine MW, et al. Coumarin-3-carboxylic acid derivatives as potentiators and inhibitors of recombinant and native N-methyl-D-aspartate receptors. Neurochem Int. 2012 Sep;61(4):593-600. Chemical & Physical Properties Molecular Formula C10H5BrO4 Exact Mass 267.93700 PSA 67.51000 LogP 2.25370 InChIKey XFQHPAXNKDYMOX-UHFFFAOYSA-N Storage condition room temp |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Shipping Name: UN |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available |
| Related Products in Specialty & Botanical Ingredients | ||
|---|---|---|
| 7-[3-(CHLORODIMETHYLSILYL)PROPOXY-4-METHYLCOUMARIN | 129119-77-3 | 2A-2176079 |
| BETA-PHENYLCINNAMALDEHYDE | 1210-39-5 | 2A-2178933 |
| 7-DIETHYLAMINO-4-(TRIFLUOROMETHYL)COUMARIN | 41934-47-8 | 2A-4178961 |
| N-(2-CARBOXY-4,5-DICHLOROBENZOYL)-(-)-10,2-CAMPHORSULTAM | 193202-37-8 | 2A-2180491 |
| HYDROXY-4-METHYL-3-COUMARINYLACETIC ACID | 5852-10-8 | 2A-2180492 |
| THYMOL-B-D-GLUCOPYRANOSIDE | 20772-23-0 | 2A-4181138 |
| 6-HYDROXY-4-METHYLCOUMARIN | 2373-31-1 | 2A-3181770 |
| 4,7-DIHYDROXYCOUMARIN | 1983-81-9 | 2A-3181772 |
| 4,7-dimethoxy coumarin | 17575-27-8 | 2A-3181773 |
| 4-hydroxy-3- nitro coumarin | 20261-31-8 | 2A-3181799 |
| Browse all Specialty & Botanical Ingredients products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS