CAS Number34233-69-7
Synonyms8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide; 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; Clozapine N-oxide; Clozapine (N-oxide)
Molecular FormulaC18H19ClN4O
Molecular Weight342.82
Density1.36g/cm3
Boiling Point517.4ºC at 760mmHg
Melting Point190-248ºC
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 34233-69-7 |
| Catalog No. | 2A-3180194 |
| Chinese Name | 氯氮平N-氧化物 |
| Synonyms | 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e](1,4)diazepine N-oxide; 8-Chloro-11-(4-methyl-4-oxido-1-piperazinyl)-5H-dibenzo[b,e][1,4]diazepine; Clozapine N-oxide; Clozapine (N-oxide) |
| Molecular Formula | C18H19ClN4O |
| Molecular Weight | 342.82 |
| Density | 1.36g/cm3 |
| Boiling Point | 517.4ºC at 760mmHg |
| Melting Point | 190-248ºC |
| Storage Condition | 2-8℃ |
| Packaging | III |
| Application | Clozapine N-oxide (CNO) is the major metabolite of the antipsychotic drug clozapine. Clozapine N-oxide is an agonist of the DREADD system. |
| PubChem ID | 24892276 |
| MDL Number | MFCD00210190 |
| SMILES | C[N+]1([O-])CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 |
| InChI | InChI=1S/C18H19ClN4O/c1-21-8-10-22(11-9-21)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)23(18)24/h2-7,12,24H,8-11H2,1H3 |
| InChI Key | OGUCZBIQSYYWEF-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352119 |
| Hazard Symbols | 6.1(b) |
| Bioactivity | Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease Target DREADD[1] In Vivo After a single intraperitoneal (i.p.) injection of Clozapine N-oxide (1 mg/kg) into mice, Clozapine N-oxide (CNO) plasma levels peak at 15 min and are very low after 2 h. Acutely administered CNO can be metabolically converted to Clozapine in other species such as human and guinea-pig. The metabolites that may form after chronic administration of CNO to DREADD-expressing mice (or other species) have not been studied systematically. However, even if back-transformation to Clozapine occurs after chronic CNO administration, it should be noted that Clozapine is a more potent (by ~10-fold) DREADD agonist than CNO itself. Moreover, confounding biological effects of potential CNO metabolites can be easily identified by including both saline- and CNO-treated WT animals in a particular DREADD study. Despite the short plasma half-life of CNO in mice, the biological effects that have been described after acute treatment of DREADD-expressing experimental animals are usually much longer (6-10 h). One possibility is that CNO tends to accumulate in tissues, although other scenarios are also feasible[1]. Using a general pharmacokinetic model for the interconversion process, the mean total clearances of Clozapine and Clozapine N-oxide (CNO) are 28.45 L/hr and 45.30 L/hr, respectively[2]. References [1]. Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. [2]. Chang WH, et al. Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):723-39. Chemical & Physical Properties Density 1.36g/cm3 Boiling Point 517.4ºC at 760mmHg Melting Point 190-248ºC Molecular Formula C18H19ClN4O Molecular Weight 342.823 Flash Point 266.7ºC Exact Mass 342.124725 PSA 57.06000 LogP 0.76 Index of Refraction 1.685 InChIKey OGUCZBIQSYYWEF-UHFFFAOYSA-N SMILES C[N+]1([O-])CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1 Storage condition 2-8℃ |
| Use of | Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system. Properties Articles15 Name clozapine n-oxide Synonym More Synonyms Clozapine N-oxide Biological Activity Description Clozapine N-oxide (CNO) is a major metabolite of the anti-psychotic drug clozapine. Clozapine N-oxide is a agonist for the chemogenetic Designer Receptors Exclusively Activated by Designer Drug (DREADD) system. Related Catalog Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor Research Areas >> Neurological Disease References [1]. Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92. [2]. Chang WH, et al. Reversible metabolism of clozapine and clozapine N-oxide in schizophrenic patients. Prog Neuropsychopharmacol Biol Psychiatry. 1998 Jul;22(5):723-39. Chemical & Physical Properties Exact Mass 342.124725 PSA 57.06000 Index of Refraction 1.685 InChIKey OGUCZBIQSYYWEF-UHFFFAOYSA-N Storage condition 2-8℃ |
| Transport Info | Product name: Purity: 97.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (Clozapine N-oxide) IMDG Code: TOXIC SOLID, ORGANIC, N.O.S. (Clozapine N-oxide) International air transport hazard regulations: Toxic solid, organic, n.o.s. (Clozapine N-oxide) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS