EAI-045

Name: EAI-045
Brand: 2A Biotech
SKU: 2A-3179940

CAS Number1942114-09-1

Synonyms2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; EAI-045

Molecular FormulaC19H14O3N3S1F1

Molecular Weight383.4

Density1.5±0.1 g/cm3

Appearancepowder

Cat. No.: 2A-3179940 Purity:

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Quality Control of [ 1942114-09-1 ] SDS Specification MoL

Chemical & Physical Properties
CAS Number	1942114-09-1
Catalog No.	2A-3179940
Chinese Name	EAI045
Synonyms	2-(5-Fluoro-2-hydroxyphenyl)-2-(1-oxo-1,3-dihydro-2H-isoindol-2-yl)-N-(1,3-thiazol-2-yl)acetamide; EAI-045
Molecular Formula	C19H14O3N3S1F1
Molecular Weight	383.4
Density	1.5±0.1 g/cm3
Appearance	powder
Storage Condition	-20℃
Application	EAI045 is an allosteric inhibitor of mutant EGFR. It inhibits EGFR at 10 μM ATP. The IC50 values of EGFRL858R, EGFRT790M and EGFRL858R/T790M are 1.9, 0.019, 0.19 and 0.002 μM respectively.
PubChem ID	315661298
MDL Number	MFCD30187871
SMILES	O=C(Nc1nccs1)C(c1cc(F)ccc1O)N1Cc2ccccc2C1=O
InChI	InChI=1S/C19H14FN3O3S/c20-12-5-6-15(24)14(9-12)16(17(25)22-19-21-7-8-27-19)23-10-11-3-1-2-4-13(11)18(23)26/h1-9,16,24H,10H2,(H,21,22,25)
InChI Key	YTUFHOKUFOQRDF-UHFFFAOYSA-N
Transport Info	Product name: EAI045

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