CAS Number527-95-7
Synonyms3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 8-Hydroxykaempferol; Herbacetin; 3,4',5,7,8-Pentahydroxyflavone; 3,4´,5,7,8-pentahydroxyflavone; 3,5,7,8,4'-pentahydroxyflavone
Molecular FormulaC15H10O7
Molecular Weight302.24
Density1.799
Boiling Point618.7±55.0 °C at 760 mmHg
Melting Point284ºC
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 527-95-7 |
| Catalog No. | 2A-1179511 |
| Chinese Name | 草质素 |
| Synonyms | 3,5,7,8-Tetrahydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 8-Hydroxykaempferol; Herbacetin; 3,4',5,7,8-Pentahydroxyflavone; 3,4´,5,7,8-pentahydroxyflavone; 3,5,7,8,4'-pentahydroxyflavone |
| Molecular Formula | C15H10O7 |
| Molecular Weight | 302.24 |
| Density | 1.799 |
| Boiling Point | 618.7±55.0 °C at 760 mmHg |
| Melting Point | 284ºC |
| Storage Condition | room temperature |
| Application | Herbacetin is a natural flavonoid found in flaxseed and has a variety of pharmacological activities, including antioxidant, anti-inflammatory and anti-cancer effects. Protamine is an allosteric inhibi |
| HTC | 2914501900 |
| PubChem ID | 5756 |
| MDL Number | MFCD00210585 |
| SMILES | O=c1c(O)c(-c2ccc(O)cc2)oc2c(O)c(O)cc(O)c12 |
| InChI | InChI=1S/C15H10O7/c16-7-3-1-6(2-4-7)14-13(21)12(20)10-8(17)5-9(18)11(19)15(10)22-14/h1-5,16-19,21H |
| InChI Key | ZDOTZEDNGNPOEW-UHFFFAOYSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| Use of | Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2]. Properties Name 3,5,7,8-tetrahydroxy-2-(4-hydroxyphenyl)chromen-4-one Synonym More Synonyms Herbacetin Biological Activity Description Herbacetin is a natural flavonoid from flaxseed, exerts various pharmacological activities, including antioxidant, anti-inflammatory and anticancer effects[1]. Herbacetin is an Ornithine decarboxylase (ODC) allosteric inhibitor, directly binds to Asp44, Asp243, and Glu384 on ODC. Ornithine decarboxylase (ODC) is a rate-limiting enzyme in the first step of polyamine biosynthesis[2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others IC50: Ornithine decarboxylase[2] References [1]. Veeramani C, et al. Herbacetin, a flaxseed flavonoid, ameliorates high percent dietary fat induced insulin resistance and lipid accumulation through the regulation of hepatic lipid metabolizing and lipid-regulating enzymes. Chem Biol Interact. 2018 May 25;288:49-56. [2]. Kim DJ, et al. Herbacetin Is a Novel Allosteric Inhibitor of Ornithine Decarboxylase with Antitumor Activity. Cancer Res. 2016 Mar 1;76(5):1146-1157. Chemical & Physical Properties Molecular Formula C15H10O7 Exact Mass 302.042664 PSA 131.36000 Index of Refraction 1.823 InChIKey ZDOTZEDNGNPOEW-UHFFFAOYSA-N Safety Information Signal Word Danger Hazard Statements H301 Precautionary Statements P301 + P310 HS Code 2914501900 Synthetic Route HERBACITRIN 35815-07-7 Herbacetin Literature: Nawwar, Mahmoud A. M.; El-Sissi, Hassan I.; Barakat, Heba H. Phytochemistry (Elsevier), 1984 , vol. 23, # 12 p. 2937 - 2940 Litvinolin 74137-44-3 Herbacetin Literature: Krasnov, E. A.; Demidenko, L. A. Chemistry of Natural Compounds, 1984 , vol. 20, # 1 p. 103 - 104 Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 1 p. 106 - 107 herbacetin 8-(3... 68385-35-3 Herbacetin Literature: Krasnov, E. A.; Demidenko, L. A. Chemistry of Natural Compounds, 1984 , vol. 20, # 1 p. 103 - 104 Khimiya Prirodnykh Soedinenii, 1984 , vol. 20, # 1 p. 106 - 107 Precursor & DownStream Precursor 9 CAS#:35815-07-7 HERBACITRIN CAS#:74137-44-3 Litvinolin CAS#:68385-35-3 herbacetin 8-(3... CAS#:72055-94-8 DownStream 0 |
| Tax Rebate | 9.0% |
| Supervision | none |
| Transport Info | Product name: Summary 2914501900 other ketone-phenols. Supervision conditions:None. VAT: 17.0%. Tax rebate rate:9.0%. MFN tariff:5.5%. General tariff:30.0% |
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