CAS Number1132709-14-8
Synonyms[(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid; N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide; HMS2089J16; (1S,2S)-Bortezomib; ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid
Molecular FormulaC19H25O4N4B1
Molecular Weight384.24
Density1.2±0.1 g/cm3
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1132709-14-8 |
| Catalog No. | 2A-3179297 |
| Chinese Name | (1S,2S)-硼替佐米 |
| Synonyms | [(1S)-1-[[(2S)-3-phenyl-2-[(pyrazine-2-carbonyl)amino]-1-oxopropyl]amino]-3-methylbutyl]boronic acid; N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide; N-[(1S)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(2-pyrazinylcarbonyl)-L-phenylalaninamide; HMS2089J16; (1S,2S)-Bortezomib; ((S)-3-Methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butyl)boronic acid |
| Molecular Formula | C19H25O4N4B1 |
| Molecular Weight | 384.24 |
| Density | 1.2±0.1 g/cm3 |
| Storage Condition | 2-8°C, dry, sealed |
| Application | (1S,2S)-Bortezomib is the enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible and selective proteasome inhibitor that potently inhibits the 20S proteasome (Ki of 0.6 nM) by targeting |
| HTC | 2934999090 |
| PubChem ID | 50125757 |
| MDL Number | MFCD05260688 |
| SMILES | CC(C)CC(NC(=O)C(Cc1ccccc1)NC(=O)c1cnccn1)B(O)O |
| InChI | InChI=1S/C19H25BN4O4/c1-13(2)10-17(20(27)28)24-18(25)15(11-14-6-4-3-5-7-14)23-19(26)16-12-21-8-9-22-16/h3-9,12-13,15,17,27-28H,10-11H2,1-2H3,(H,23,26)(H,24,25)/t15-,17+/m0/s1 |
| InChI Key | GXJABQQUPOEUTA-DOTOQJQBSA-N |
| Use of | (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans[1][2][3]. Properties Name [(1S)-3-methyl-1-[[(2S)-3-phenyl-2-(pyrazine-2-carbonylamino)propanoyl]amino]butyl]boronic acid Synonym More Synonyms (1S,2S)-Bortezomib Biological Activity Description (1S,2S)-Bortezomib is an enantiomer of Bortezomib. Bortezomib is a cell-permeable, reversible, and selective proteasome inhibitor, and potently inhibits 20S proteasome (Ki of 0.6 nM) by targeting a threonine residue. Bortezomib disrupts the cell cycle, induces apoptosis, and inhibits NF-κB. Bortezomib is an anti-cancer agent and the first therapeutic proteasome inhibitor to be used in humans[1][2][3]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Proteasome Ki: 0.6 nM (20S proteasome)[1] References [1]. Kamalzadeh Z, et al. Determination of Bortezomib in API Samples Using HPLC: Assessment of Enantiomeric and Diastereomeric Impurities. J Chromatogr Sci. 2017 Aug 1;55(7):697-705. [2]. Adams J, et al. Proteasome inhibitors: a novel class of potent and effective antitumor agents. Cancer Res. 1999 Jun 1;59(11):2615-22. [3]. Shahshahan MA, et al. Potential usage of proteasome inhibitor bortezomib (Velcade, PS-341) in the treatment of metastaticmelanoma: basic and clinical aspects. Am J Cancer Res. 2011;1(7):913-24. Chemical & Physical Properties Molecular Formula C19H25BN4O4 Exact Mass 384.196899 PSA 131.42000 Index of Refraction 1.564 InChIKey GXJABQQUPOEUTA-DOTOQJQBSA-N Safety Information Hazard Codes Xi HS Code 2934999090 Synthetic Route Total: 1 Page benzyl ((S)-1-(... CAS#:1422969-07-0 (1S,2S)-Bortezomib CAS#:1132709-14-8 Literature: Peuchmaur, Marine; Lacour, Marie-Agnes; Sevalle, Jean; Lisowski, Vincent; Touati-Jallabe, Youness; Rodier, Fabien; Martinez, Jean; Checler, Frederic; Hernandez, Jean-Francois Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 1018 - 1029 N-Cbz-L-Phenyla... CAS#:1161-13-3 (1S,2S)-Bortezomib CAS#:1132709-14-8 Literature: Peuchmaur, Marine; Lacour, Marie-Agnes; Sevalle, Jean; Lisowski, Vincent; Touati-Jallabe, Youness; Rodier, Fabien; Martinez, Jean; Checler, Frederic; Hernandez, Jean-Francois Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 4 p. 1018 - 1029 Precursor & DownStream Precursor 1 CAS#:1161-13-3 N-Cbz-L-Phenyla... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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