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HYDROXYZINE PAMOATE structure, CAS 10246-75-0

HYDROXYZINE PAMOATE

CAS Number10246-75-0

SynonymsPaxistil {Pamoate}; Equipose {Pamoate}; Paxisitil; Bobsule; Atarax P; Hydroxyzine pamoate salt; hydroxyzine pamoate; Hydroxyzyne pamoate; EINECS 233-582-1; Hydroxyzine embonate; Hydroxyzine (pamoate)

Molecular FormulaC44H43ClN2O8

Molecular Weight763.27

Purity

Density1.182g/cm3

Boiling Point499.2ºC at 760mmHg

Melting Point

Flash Point

Appearancepowder

EINECS

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Cat. No.: 2A-2178624 Purity:
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Chemical & Physical Properties
CAS Number10246-75-0
Catalog No.2A-2178624
Chinese Name双羟萘酸羟嗪
SynonymsPaxistil {Pamoate}; Equipose {Pamoate}; Paxisitil; Bobsule; Atarax P; Hydroxyzine pamoate salt; hydroxyzine pamoate; Hydroxyzyne pamoate; EINECS 233-582-1; Hydroxyzine embonate; Hydroxyzine (pamoate)
Molecular FormulaC44H43ClN2O8
Molecular Weight763.27
Density1.182g/cm3
Boiling Point499.2ºC at 760mmHg
Appearancepowder
Storage Condition-20℃
ApplicationHydroxyzine pamoate is a histamine receptor H1 antagonist.
PubChem ID329750142
MDL NumberMFCD00058051
SMILESClC1=CC=C(C=C1)C(N2CCN(CCOCCO)CC2)C3=CC=CC=C3.O=C(O)C4=C(O)C(CC5=C(C=CC=C6)C6=CC(C(O)=O)=C5O)=C7C=CC=CC7=C4
InChI1S/C23H16O6.C21H27ClN2O2/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-10,24-25H,11H2,(H,26,27)(H,28,29);1-9,21,25H,10-17H2
InChI KeyASDOKGIIKXGMNB-UHFFFAOYSA-N
NACRES CodeNA.24
UNSPSC41116107
Hazard Symbolstransportation
MSDSmsds/179295_1_10246_75_0.pdf
BioactivityHydroxyzine pamoate is a histamine H1-receptor antagonist.Target: Histamine H1-ReceptorHydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1]. Hydroxyzine (0.1 mM) treatment inhibits the progression and severity of EAE by 50% and the extent of mast cell degranulation by 70% in Lewis rats with allergic encephalomyelitis (EAE) [2]. Hydroxyzine (500 M) significantly increases transport of etoposide to the serosal site in the jejunal everted sacs. Hydroxyzine significantly reduces the efflux and approximately 2.4 ug/mL of etoposide in the jejunum and ileum. Hydroxyzine (0.2 μg/mL) significantly enhances the efflux of RH123 to the lumen [3].Hydroxyzine (500 μM) significantly decreases the steady-state etoposide concentration 2-fold, where the steady-state concentration reached about 0.055 μM/mL in Sprague-Dawley rats [3]. Hydroxyzine (12.5 mg/kg, 25 mg/kg and 50 mg/kg i.p.) shows little direct analgesic activity but markedly potentiates only the effect of morphine on the vocalization after-discharge which represents the affective component of pain in rats. Hydroxyzine (50 mg/kg i.p.) potentiates morphine on the tail-flick test, while Hydroxyzine (12.5 mg/kg i.p.) decreases morphine antinociception in rats [4]. Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63. [2]. Dimitriadou, V., X. Pang, and T.C. Theoharides, Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation. Int J Immunopharmacol, 2000. 22(9): p. 673-84. [3]. Kan, W.M., et al., Effect of hydroxyzine on the transport of etoposide in rat small intestine. Anticancer Drugs, 2001. 12(3): p. 267-73. [4]. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7(2): p. 173-80. Chemical & Physical Properties Density 1.182g/cm3 Boiling Point 499.2ºC at 760mmHg Molecular Formula C44H43ClN2O8 Molecular Weight 763.274 Flash Point 255.7ºC Exact Mass 762.270813 PSA 151.00000 LogP 7.32310 Vapour Pressure 2.13E-17mmHg at 25°C InChIKey ASDOKGIIKXGMNB-UHFFFAOYSA-N SMILES O=C(O)c1cc2ccccc2c(Cc2c(O)c(C(=O)O)cc3ccccc23)c1O.OCCOCCN1CCN(C(c2ccccc2)c2ccc(Cl)cc2)CC1 Storage condition -20℃
Use ofProperties Articles26 Name hydroxyzine pamoate Synonym More Synonyms Hydroxyzine (pamoate) Biological Activity Related Catalog Signaling Pathways >> GPCR/G Protein >> Histamine Receptor Signaling Pathways >> Immunology/Inflammation >> Histamine Receptor Research Areas >> Inflammation/Immunology References [1]. Minogiannis, P., et al., Hydroxyzine inhibits neurogenic bladder mast cell activation. Int J Immunopharmacol, 1998. 20(10): p. 553-63. [2]. Dimitriadou, V., X. Pang, and T.C. Theoharides, Hydroxyzine inhibits experimental allergic encephalomyelitis (EAE) and associated brain mast cell activation. Int J Immunopharmacol, 2000. 22(9): p. 673-84. [3]. Kan, W.M., et al., Effect of hydroxyzine on the transport of etoposide in rat small intestine. Anticancer Drugs, 2001. 12(3): p. 267-73. [4]. Morichi, R. and G. Pepeu, A study of the influence of hydroxyzine and diazepam on morphine antinociceptoion in the rat. Pain, 1979. 7(2): p. 173-80. Chemical & Physical Properties Exact Mass 762.270813 PSA 151.00000 LogP 7.32310 InChIKey ASDOKGIIKXGMNB-UHFFFAOYSA-N Storage condition -20℃
Transport InfoShipping Name: UN
MSDS Transport InfoModule 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 United Nations shipping name European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Danger Regulations: No International Maritime Danger Regulations International Air Transport Danger Regulations: No Marine pollutants (yes/no): No 14.6 Special reminder to users No data available
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