CAS Number625115-52-8
SynonymsMethyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl}carbamate; Bay 60-4552; Nelociguat; Nelociguat [INN]
Molecular FormulaC19H17O2N8F1
Molecular Weight408.39
Density1.6±0.1 g/cm3
Boiling Point533.3±50.0 °C at 760 mmHg
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 625115-52-8 |
| Catalog No. | 2A-3178320 |
| Chinese Name | Nelociguat |
| Synonyms | Methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]-5-pyrimidinyl}carbamate; Bay 60-4552; Nelociguat; Nelociguat [INN] |
| Molecular Formula | C19H17O2N8F1 |
| Molecular Weight | 408.39 |
| Density | 1.6±0.1 g/cm3 |
| Boiling Point | 533.3±50.0 °C at 760 mmHg |
| Storage Condition | 2-8℃ |
| Application | Nelociguat (BAY60-4552) is a nitric oxide-sensitive soluble guanylate cyclase activator. |
| HTC | 2933990090 |
| MDL Number | MFCD22741546 |
| SMILES | COC(=O)Nc1c(N)nc(-c2nn(Cc3ccccc3F)c3ncccc23)nc1N |
| InChI Key | FTQHGWIXJSSWOY-UHFFFAOYSA-N |
| MSDS | msds/178958_1_625115_52_8.pdf |
| Use of | Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator. Properties Name methyl N-[4,6-diamino-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl]carbamate Synonym More Synonyms Nelociguat Biological Activity Description Nelociguat (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator. Related Catalog Signaling Pathways >> GPCR/G Protein >> Guanylate Cyclase Research Areas >> Cardiovascular Disease References [1]. Costell MH, et al. Comparison of soluble guanylate cyclase stimulators and activators in models of cardiovascular disease associated with oxidative stress. Front Pharmacol. 2012 Jul 5;3:128. [2]. Zhao X, et al. Pharmacokinetics of the Soluble Guanylate Cyclase Stimulator Riociguat in Healthy Young Chinese Male Non-Smokers and Smokers: Results of a Randomized, Double-Blind, Placebo-Controlled Study. Clin Pharmacokinet. 2016 May;55(5):615-24. [3]. Oudot A, et al. Combination of BAY 60-4552 and vardenafil exerts proerectile facilitator effects in rats with cavernous nerve injury: a proof of concept study for the treatment of phosphodiesterase type 5 inhibitor failure. Eur Urol. 2011 Nov;60(5):1020-6. Chemical & Physical Properties Molecular Formula C19H17FN8O2 Exact Mass 408.145844 PSA 151.08000 LogP -0.10 Index of Refraction 1.748 InChIKey FTQHGWIXJSSWOY-UHFFFAOYSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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