CAS Number500287-72-9
Synonyms[3H]-Rilpivirine; Edurant; Rilpivirine; TMC-278; 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile; 4-{[4-({4-[(E)-2-Cyanovinyl]-2,6-dimethylphenyl}amino)-2-pyrimidinyl]amino}benzonitrile; UNII-FI96A8X663; R 278474; BENZONITRILE,4-((4-((4-((1E)-2-CYANOETHEN YL)-2,6-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)AMINO)-)
Molecular FormulaC22H18N6
Molecular Weight366.42
Purity≥98 (HPLC)%
Density1.3±0.1 g/cm3
Boiling Point634.1±65.0 °C at 760 mmHg
Melting Point245ºC
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 500287-72-9 |
| Catalog No. | 2A-3178319 |
| Chinese Name | 利匹韦林 |
| Synonyms | [3H]-Rilpivirine; Edurant; Rilpivirine; TMC-278; 4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile; 4-{[4-({4-[(E)-2-Cyanovinyl]-2,6-dimethylphenyl}amino)-2-pyrimidinyl]amino}benzonitrile; UNII-FI96A8X663; R 278474; BENZONITRILE,4-((4-((4-((1E)-2-CYANOETHEN YL)-2,6-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)AMINO)-) |
| Molecular Formula | C22H18N6 |
| Molecular Weight | 366.42 |
| Purity | ≥98 (HPLC) |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 634.1±65.0 °C at 760 mmHg |
| Melting Point | 245ºC |
| Appearance | powder |
| Storage Condition | Refrigerator |
| Application | Rilpivirine (R278474; TMC278) is a non-nucleoside reverse transcriptase inhibitor of HIV. |
| HTC | 2933599090 |
| MDL Number | MFCD11046372 |
| SMILES | CC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N |
| InChI | 1S/C22H18N6/c1-15-12-18(4-3-10-23)13-16(2)21(15)27-20-9-11-25-22(28-20)26-19-7-5-17(14-24)6-8-19/h3-9,11-13H,1-2H3,(H2,25,26,27,28)/b4-3+ |
| InChI Key | YIBOMRUWOWDFLG-ONEGZZNKSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 51111800 |
| MSDS | msds/178957_1_500287_72_9.pdf |
| Use of | Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). Properties Name rilpivirine Synonym More Synonyms Rilpivirine Biological Activity Description Rilpivirine (R278474; TMC278) is a type of anti-HIV medicine called a non-nucleoside reverse transcriptase inhibitor (NNRTI). Related Catalog Signaling Pathways >> Anti-infection >> HIV Signaling Pathways >> Anti-infection >> Reverse Transcriptase Research Areas >> Infection In Vitro Rilpivirine(TMC278) is a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1. NNRTIs work by binding to and blocking HIV reverse transcriptase, an HIV enzyme. This prevents HIV from replicating and lowers the amount of HIV in the blood. References [1]. Singh K, Marchand B, Rai DK, Sharma B, Michailidis E, Ryan EM, Matzek KB, Leslie MD, Hagedorn AN, Li Z, Norden PR, Hachiya A, Parniak MA, Xu HT, Wainberg MA, Sarafianos SG.Biochemical Mechanism of HIV-1 Resistance to Rilpivirine.J Biol Chem. 2012 Sep 6. [2]. Schafer JJ, Short WR.Rilpivirine, a novel non-nucleoside reverse transcriptase inhibitor for the management of HIV-1 infection: a systematic review.Antivir Ther. 2012 Jul 25. [3]. Vingerhoets J, Rimsky L, Van Eygen V, Nijs S, Vanveggel S, Boven K, Picchio G.Preexisting mutations in the rilpivirine Phase III trials ECHO and THRIVE: prevalence and impact on virologic response.Antivir Ther. 2012 Sep 6. [4]. Gomes T, Juurlink DN, Mamdani MM.Comparative adherence to oxybutynin or tolterodine among older patients.Eur J Clin Pharmacol. 2012 Jan;68(1):97-9. Epub 2011 Jun 28. [5]. Azijn, Hilde et al. TMC278, a next-generation nonnucleoside reverse transcriptase inhibitor (NNRTI), active against wild-type and NNRTI-resistant HIV-1.Antimicrobial Agents and Chemotherapy (2010), 54(2), 718-727. Chemical & Physical Properties Molecular Formula C22H18N6 Exact Mass 366.159302 PSA 97.42000 Index of Refraction 1.665 InChIKey YIBOMRUWOWDFLG-ONEGZZNKSA-N Storage condition Refrigerator Safety Information Hazard Codes Xi HS Code 2933599090 Synthetic Route (E)-3-(4-(2-chl... 1538550-43-4 4-Aminobenzonit... Rilpivirine 500287-72-9 4-[(4-Chloro-2-... 244768-32-9 Rilpivirine 500287-72-9 4-bromo-2,6-xyl... 24596-19-8 Rilpivirine 500287-72-9 Literature: Guillemont, Jerome; Pasquier, Elisabeth; Palandjian, Patrice; Vernier, Daniel; Gaurrand, Sandrine; Lewi, Paul J.; Heeres, Jan; De Jonge, Marc R.; Koymans, Lucien M. H.; Daeyaert, Frits F. D.; Vinkers, Maarten H.; Arnold, Eddy; Das, Kalyan; Pauwels, Rudi; Andries, Koen; De Bethune, Marie-Pierre; Bettens, Eva; Hertogs, Kurt; Wigerinck, Piet; Timmerman, Philip; Janssen, Paul A. J. Journal of Medicinal Chemistry, 2005 , vol. 48, # 6 p. 2072 - 2079 Precursor & DownStream Precursor 9 CAS#:873-74-5 4-Aminobenzonitrile CAS#:244768-32-9 4-[(4-Chloro-2-... CAS#:24596-19-8 4-bromo-2,6-xylidine CAS#:3095-47-4 Ethyl 4-amino-3... DownStream 1 CAS#:700361-47-3 rilpivirine hyd... |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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| AFP-CTF urea impurity (Regorafenib impurity) | 1333390-56-9 | 2A-3178311 |
| N-Desmethyl Regorafenib N-Oxide | 835621-12-0 | 2A-3178312 |
| Desmethyl Rifampicin | 13292-45-0 | 2A-3178315 |
| Rilpivirine Z-isomer | 500287-94-5 | 2A-3178318 |
| Ritonavir N acetyl impurity (Imp C) | 1010808-43-1 | 2A-3178322 |
| Rosuvastatin S- isomer | 2A-3178331 | 2A-3178331 |
| Rosuvastatin 3R,5R-Isomer calcium | 1094100-06-7 | 2A-3178333 |
| Rosuvastatin 3S,5R - isomer calcium | 242184-42-4 | 2A-3178334 |
| Rosuvastatin 5-keto acid impurity | 1422619-13-3 | 2A-3178335 |
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