CAS Number843666-27-3
Synonymsmono-tert-butyl hexadecandioate; hexadecanedioic acid mono-tert-butyl ester; tert-Butyl hydrogen hexadecanedioate
Molecular FormulaC20H38O4
Molecular Weight342.52
Density0.959±0.06 g/cm3
Melting Point58.0-62.0°C
AppearanceWhite off-white crystal-powder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 843666-27-3 |
| Catalog No. | 2A-2177913 |
| Chinese Name | 十六烷基二酸单叔丁酯 |
| Synonyms | mono-tert-butyl hexadecandioate; hexadecanedioic acid mono-tert-butyl ester; tert-Butyl hydrogen hexadecanedioate |
| Molecular Formula | C20H38O4 |
| Molecular Weight | 342.52 |
| Density | 0.959±0.06 g/cm3 |
| Melting Point | 58.0-62.0°C |
| Appearance | White off-white crystal-powder |
| Water Solubility | Insuluble (2.9E-3 g/L) (25 ºC) |
| Storage Condition | room temperature |
| Application | Boc-C14-COOH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADC). Boc-C14-COOH is also a PROTAC linker based on alkyl chains and can be used to synthesize PROTAC[1][2]. |
| HTC | 2918990090 |
| MDL Number | MFCD23136039 |
| MSDS | msds/178517_1_843666_27_3.pdf |
| Use of | Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Properties Name 16-[(2-methylpropan-2-yl)oxy]-16-oxohexadecanoate Synonym More Synonyms Boc-C14-COOH Biological Activity Description Boc-C14-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C14-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C20H38O4 Exact Mass 341.26900 PSA 66.43000 LogP 4.53940 Safety Information HS Code 2918990090 Synthetic Route Total: 1 Page Hexadecanedioic acid CAS#:505-54-4 1,1-Di-tert-but... CAS#:36805-97-7 Boc-C14-COOH CAS#:843666-27-3 Precursor & DownStream Precursor 2 CAS#:505-54-4 Hexadecanedioic acid CAS#:36805-97-7 1,1-Di-tert-but... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 4-METHOXYBENZYL-2,2,2-TRICHLOROACETIMID | 89238-99-3 | 2A-2177908 |
| ETHYLL-4-CHLORO-3-HYDROXY BUTYRATE | 10488-69-4 | 2A-2177909 |
| ETHYL 4-PENTENOATE | 1968-40-7 | 2A-2177910 |
| L-GLUTAMIC BENZYL ESTER | 54322-10-0 | 2A-2177911 |
| 2-Methylpentanedioic acid dimethyl ester | 14035-94-0 | 2A-2177912 |
| Heptadecanedioic acid mono-tert-butyl ester | 905302-44-5 | 2A-2177914 |
| 2-Cyanopropionic acid methyl ester | 14618-77-0 | 2A-2177915 |
| ETHYL GLUTARYL CHLORIDE | 5205-39-0 | 2A-2177917 |
| DODECANEDIOIC ACID MONOMETHYL ESTER | 3903-40-0 | 2A-2177918 |
| DIBENZYL SUCCINATE | 103-43-5 | 2A-2177919 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS