CAS Number11041-94-4
Synonymspyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one; 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1); 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; Higenamine HCl; UNII:PQ432PID6E; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1)
Molecular FormulaC16H18ClNO3
Molecular Weight307.77
Purity≥95 (HPLC)%
Boiling Point522.4ºC at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 11041-94-4 |
| Catalog No. | 2A-1177901 |
| Chinese Name | 盐酸去甲乌药碱 |
| Synonyms | pyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one; 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydrochloride (1:1); 6,7-dihydroxy-1-(4-hydroxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; Higenamine HCl; UNII:PQ432PID6E; 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-[(4-hydroxyphenyl)methyl]-, hydrochloride (1:1) |
| Molecular Formula | C16H18ClNO3 |
| Molecular Weight | 307.77 |
| Purity | ≥95 (HPLC) |
| Boiling Point | 522.4ºC at 760 mmHg |
| Appearance | powder |
| Storage Condition | room temperature, dry |
| Application | Higenamine hydrochloride (Norcoclaurine hydrochloride) is a β2-AR agonist and a key component of Aconitum, a traditional Chinese medicine used to treat heart failure in East Asian countries. Higenamin |
| HTC | 2933499090 |
| MDL Number | MFCD01717353 |
| SMILES | OC1=C(O)C=C(C(CC2=CC=C(O)C=C2)NCC3)C3=C1.Cl |
| InChI | 1S/C16H17NO3.ClH/c18-12-3-1-10(2-4-12)7-14-13-9-16(20)15(19)8-11(13)5-6-17-14;/h1-4,8-9,14,17-20H,5-7H2;1H |
| InChI Key | SWWQQSDRUYSMAR-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352116 |
| MSDS | msds/178504_1_11041_94_4.pdf |
| Use of | Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2]. Properties Name 1-(4-Hydroxybenzyl)-1,2,3,4-tetrahydro-6,7-isoquinolinediol hydro chloride (1:1) Synonym More Synonyms Higenamine HCl Biological Activity Description Higenamine hydrochloride (Norcoclaurine hydrochloride), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. Higenamine hydrochloride (Norcoclaurine hydrochloride) has anti-apoptotic effects[1][2]. Related Catalog Signaling Pathways >> Apoptosis >> Apoptosis Research Areas >> Cancer Research Areas >> Endocrinology References [1]. Wu MP, et al. Higenamine protects ischemia/reperfusion induced cardiac injury and myocyte apoptosis through activation of β2-AR/PI3K/AKT signaling pathway. Pharmacol Res. 2016 Feb;104:115-23. [2]. Lee SR, et al. Acute oral intake of a higenamine-based dietary supplement increases circulating free fatty acidsand energy expenditure in human subjects. Lipids Health Dis. 2013 Oct 21;12:148. Chemical & Physical Properties Exact Mass 307.097534 PSA 72.72000 LogP 3.36370 InChIKey SWWQQSDRUYSMAR-UHFFFAOYSA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : 6,7-Isoquinolinediol, 1,2,3,4-tetrahydro-1-((4-hydroxyphenyl)methyl)-, hydrochloride, (+-)- CAS REGISTRY NUMBER : 11041-94-4 LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : MOLECULAR WEIGHT : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 17250 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : CTYAD8 Zhongcaoyao. Chinese Traditional and Herbal Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.11- 1980- Volume(issue)/page/year: 13,489,1982 Safety Information HS Code 2933499090 Synthetic Route CAS#:117765-29-4 Higenamine HCl CAS#:11041-94-4 Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029 4-Benzyloxyphen... CAS#:838-96-0 Higenamine HCl CAS#:11041-94-4 Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029 TRANS-3 4-BENZY... CAS#:1699-54-3 Higenamine HCl CAS#:11041-94-4 Literature: Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2016 - 2029 Precursor & DownStream Precursor 7 CAS#:838-96-0 4-Benzyloxyphen... CAS#:1699-54-3 TRANS-3 4-BENZY... CAS#:39188-62-0 4-Benzyloxyphen... CAS#:6547-53-1 [4-(Benzyloxy)p... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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