CAS Number71-62-5
SynonymsMetergoline; ,4alpha,16beta); EINECS 200-758-4; Veracevine,veratrate; ybenzoate); VERATRIDINE; 3-VERATROYLVERACEVINE; MFCD00082515
Molecular FormulaC36H51NO11
Molecular Weight673.79
Purity≥98 (TLC)%
Density1.45 g/cm3
Boiling Point814.5ºC at 760 mmHg
Melting Point180ºC
Appearancesolid
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 71-62-5 |
| Catalog No. | 2A-1177771 |
| Chinese Name | 藜芦定 |
| Synonyms | Metergoline; ,4alpha,16beta); EINECS 200-758-4; Veracevine,veratrate; ybenzoate); VERATRIDINE; 3-VERATROYLVERACEVINE; MFCD00082515 |
| Molecular Formula | C36H51NO11 |
| Molecular Weight | 673.79 |
| Purity | ≥98 (TLC) |
| Density | 1.45 g/cm3 |
| Boiling Point | 814.5ºC at 760 mmHg |
| Melting Point | 180ºC |
| Appearance | solid |
| Storage Condition | This product should be stored in a sealed, cool, d |
| Packaging | II |
| Application | Veratridine (3-Veratroylveracevine) is an alkaloid from a plant in the Liliaceae family and is a sodium channel agonist. Veratridine inhibits Nav1.7 peak current with an IC50 of 18.39 µM. |
| HTC | 2929101000 |
| MDL Number | MFCD00082515 |
| SMILES | N21[C@H]([C@]([C@@]3([C@H]([C@]4([C@]([C@H]5[C@]6(O[C@]7([C@H]([C@@]6(CC[C@@H]7OC(=O)c8cc(c(cc8)OC)OC)C)CC5)O)C4)(C[C@@H]3O)O)O)C2)O)(O)C)CC[C@@H](C1)C |
| InChI | 1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1 |
| InChI Key | FVECELJHCSPHKY-YFUMOZOISA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| Hazard Symbols | 6.1(a) |
| MSDS | msds/178366_1_71_62_5.pdf |
| Use of | Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Properties Articles53 Name veratridine Synonym More Synonyms Veratridine Biological Activity Description Veratridine (3-Veratroylveracevine), a alkaloid derived from plants in the family Liliaceae, is a sodium channel agonist. Veratridine inhibits the peak current of Nav1.7, with an IC50 of 18.39 µM. Related Catalog Signaling Pathways >> Membrane Transporter/Ion Channel >> Sodium Channel Research Areas >> Neurological Disease References [1]. Zhang XY, et al. Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7. Acta Pharmacol Sin. 2018 Nov;39(11):1716-1724. Chemical & Physical Properties Molecular Formula C36H51NO11 Exact Mass 673.34600 PSA 178.61000 LogP 1.29390 Index of Refraction 1.663 InChIKey FVECELJHCSPHKY-YFUMOZOISA-N Toxicological Information CHEMICAL IDENTIFICATION RTECS NUMBER : CHEMICAL NAME : Veratridine CAS REGISTRY NUMBER : BEILSTEIN REFERENCE NO. : LAST UPDATED : DATA ITEMS CITED : MOLECULAR FORMULA : C36-H51-N-O11 MOLECULAR WEIGHT : WISWESSER LINE NOTATION : HEALTH HAZARD DATA ACUTE TOXICITY DATA TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - rat DOSE/DURATION : 3500 ug/kg TOXIC EFFECTS : REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Intraperitoneal SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 1350 ug/kg TOXIC EFFECTS : Details of toxic effects not reported other than lethal dose value REFERENCE : TYPE OF TEST : LD50 - Lethal dose, 50 percent kill ROUTE OF EXPOSURE : Subcutaneous SPECIES OBSERVED : Rodent - mouse DOSE/DURATION : 6300 ug/kg TOXIC EFFECTS : Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis REFERENCE : TYPE OF TEST : LDLo - Lowest published lethal dose ROUTE OF EXPOSURE : Intravenous SPECIES OBSERVED : Mammal - dog DOSE/DURATION : TOXIC EFFECTS : Cardiac - arrhythmias (including changes in conduction) REFERENCE : Safety Information GHS06, GHS08 Signal Word Danger Hazard Statements H300 + H310 + H330-H315-H319-H335-H361-H373-H412 Precautionary Statements P260-P262-P280-P301 + P310 + P330-P302 + P352 + P310-P304 + P340 + P310-P403 + P233 Personal Protective Equipment dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges Hazard Codes T+: Very toxic; RIDADR UN 1544 6 WGK Germany 2 RTECS YX5600000 Packaging Group II Hazard Class 6.1(a) HS Code 2929101000 Synthetic Route Total: 1 Page veratroyl chloride CAS#:3535-37-3 Veratridine CAS#:71-62-5 Literature: Collection of Czechoslovak Chemical Communications, , vol. 22, p. 98,102 Precursor & DownStream Precursor 1 CAS#:3535-37-3 veratroyl chloride DownStream 2 CAS#:93-07-2 Veratric acid CAS#:124-98-1 Cevane-3,4,12,1... |
| Tax Rebate | 9.0% |
| Supervision | None. Minimum tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2929101000. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:6.5%. General tariff:30.0% |
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