CAS Number104746-04-5
Synonyms(+)-Licarbazepine; (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide; (S)-(+)-licarbazepine; T C676 BN&T&J BVZ IQ &&S Form; MHD; (S)-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; Eslicarbazepine; 5-hydroxy-4a,5-dihydro-4H-dibenzo[b,f]azepine-10-carboxamide; (10S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; S-licarbazepine; (S)-Licarbazepine; S5VXA428R4
Molecular FormulaC15H14O2N2
Molecular Weight254.29
Density1.3±0.1 g/cm3
Boiling Point431.3±55.0 °C at 760 mmHg
Melting Point188-190°C
Appearanceoff-white solid
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 104746-04-5 |
| Catalog No. | 2A-3177631 |
| Chinese Name | 艾司利卡西平 |
| Synonyms | (+)-Licarbazepine; (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide; (S)-(+)-licarbazepine; T C676 BN&T&J BVZ IQ &&S Form; MHD; (S)-10-hydroxy-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide; Eslicarbazepine; 5-hydroxy-4a,5-dihydro-4H-dibenzo[b,f]azepine-10-carboxamide; (10S)-10-Hydroxy-10,11-dihydro-5H-dibenzo[b,f]azepine-5-carboxamide; S-licarbazepine; (S)-Licarbazepine; S5VXA428R4 |
| Molecular Formula | C15H14O2N2 |
| Molecular Weight | 254.29 |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 431.3±55.0 °C at 760 mmHg |
| Melting Point | 188-190°C |
| Appearance | off-white solid |
| Storage Condition | 2-8℃ |
| Application | Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial epilepsy. |
| HTC | 2933990090 |
| MDL Number | MFCD08460933 |
| SMILES | NC(=O)N1c2ccccc2CC(O)c2ccccc21 |
| InChI Key | BMPDWHIDQYTSHX-AWEZNQCLSA-N |
| Use of | Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures. Properties Name Eslicarbazepine Synonym More Synonyms Eslicarbazepine Biological Activity Description Eslicarbazepine is an oral anticonvulsant indicated for the adjunctive treatment of partial seizures. Related Catalog Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease In Vivo Eslicarbazepine is an anti-epileptic drug, chemically related to carbamazepine but with a more favorable safety profile. Eslicarbazepine acetate is a prodrug for eslicarbazepine (S-licarbazepine), which is a dual a dual Inhibitor of β-Secretase and voltage-gated sodium channel[1][2]. References [1]. Finelli E, et al. Patch testing in a case of eslicarbazepine and carbamazepine induced cutaneous reaction. Eur Ann Allergy Clin Immunol. 2018 Sep;50(5):229-231. [2]. Sibhghatulla Shaikh, et al. Aptiom (Eslicarbazepine Acetate) as a Dual Inhibitor of β-Secretase and Voltage-Gated Sodium Channel: Advancement in Alzheimer's Disease-Epilepsy Linkage via an Enzoinformatics Study. CNS & Neurological Disorders Drug Targets Volume 13 , Issue 7 , 2014. Chemical & Physical Properties Molecular Formula C15H14N2O2 Exact Mass 254.105530 PSA 66.56000 Index of Refraction 1.677 InChIKey BMPDWHIDQYTSHX-AWEZNQCLSA-N Storage condition 2-8℃ Safety Information HS Code 2933990090 Synthetic Route Oxcarbazepine 28721-07-5 Eslicarbazepine 104746-04-5 5-Carbamoyl-5H-... 356760-08-2 Eslicarbazepine 104746-04-5 (2R,3R)-2,3-dia... 475674-43-2 Eslicarbazepine 104746-04-5 Precursor & DownStream Precursor 6 CAS#:28721-07-5 Oxcarbazepine CAS#:356760-08-2 5-Carbamoyl-5H-... CAS#:1335227-37-6 (10S)-10-[(2R)-... CAS#:29331-92-8 Licarbazepine DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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