CAS Number344458-15-7
Synonyms2-Phenanthridineacetamide, 5,6-dihydro-N,N-dimethyl-6-oxo-, hydrochloride (1:1); 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride; s7300; PJ-34 hydrochloride hydrate; PJ 34 Hydrochloride; N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride (1:1); Acetamide (N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino); N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride; N,N-Dimethyl-2-(6-oxo-5,6-dihydro-2-phenanthridinyl)acetamide hydrochloride (1:1); PJ34 HCl; PJ34 (hydrochloride)
Molecular FormulaC17H18ClN3O2
Molecular Weight331.80 (anhydrous basis)
Purity≥98 (HPLC)%
Boiling Point539.1ºC at 760 mmHg
Appearancepowder
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 344458-15-7 |
| Catalog No. | 2A-1176939 |
| Chinese Name | PJ34盐酸盐 |
| Synonyms | 2-Phenanthridineacetamide, 5,6-dihydro-N,N-dimethyl-6-oxo-, hydrochloride (1:1); 2-(Dimethylamino)-N-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride; s7300; PJ-34 hydrochloride hydrate; PJ 34 Hydrochloride; N,N-Dimethyl-2-(6-oxo-5,6-dihydrophenanthridin-2-yl)acetamide hydrochloride (1:1); Acetamide (N-(5,6-dihydro-6-oxo-2-phenanthridinyl)-2-(dimethylamino); N-(6-Oxo-5,6-dihydrophenanthridin-2-yl)-(N,N-dimethylamino)acetamide hydrochloride; N,N-Dimethyl-2-(6-oxo-5,6-dihydro-2-phenanthridinyl)acetamide hydrochloride (1:1); PJ34 HCl; PJ34 (hydrochloride) |
| Molecular Formula | C17H18ClN3O2 |
| Molecular Weight | 331.80 (anhydrous basis) |
| Purity | ≥98 (HPLC) |
| Boiling Point | 539.1ºC at 760 mmHg |
| Appearance | powder |
| Water Solubility | H2O: soluble22mg/mL |
| Storage Condition | Desiccate at RT |
| Application | PJ34 hydrochloride is an inhibitor of PARPl1/2 with IC50 values of 110 nM and 86 nM respectively. |
| HTC | 2933990090 |
| PubChem ID | 24898531 |
| SMILES | Cl[H].[H]O[H].CN(C)CC(=O)Nc1ccc2NC(=O)c3ccccc3-c2c1 |
| InChI | 1S/C17H17N3O2.ClH.H2O/c1-20(2)10-16(21)18-11-7-8-15-14(9-11)12-5-3-4-6-13(12)17(22)19-15;;/h3-9H,10H2,1-2H3,(H,18,21)(H,19,22);1H;1H2 |
| InChI Key | YCALIZUKAFUQCH-UHFFFAOYSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/177480_1_344458_15_7.pdf |
| Use of | Properties Name 2-(dimethylamino)-N-(6-oxo-5H-phenanthridin-2-yl)acetamide,hydrochloride Synonym More Synonyms PJ34 HCl Biological Activity Related Catalog Signaling Pathways >> Cell Cycle/DNA Damage >> PARP Signaling Pathways >> Epigenetics >> PARP Research Areas >> Cancer PARP-2:86 nM (IC50) PARP-1:110 nM (IC50) PARP:110 nM (IC50) References [1]. Iwashita A, et al. A novel and potent poly(ADP-ribose) polymerase-1 inhibitor, FR247304 (5-chloro-2-[3-(4-phenyl-3,6-dihydro-1(2H)-pyridinyl)propyl]-4(3H)-quinazolinone), attenuates neuronal damage in in vitro and in vivo models of cerebral ischemia. J Ph [2]. Haddad M, et al. Anti-inflammatory effects of PJ34, a poly(ADP-ribose) polymerase inhibitor, in transient focal cerebral ischemia in mice. Br J Pharmacol. 2006 Sep;149(1):23-30. [3]. Diani-Moore S, et al. NAD+ loss, a new player in AhR biology: prevention of thymus atrophy and hepatosteatosis by NAD+ repletion. Sci Rep. 2017 May 23;7(1):2268. Chemical & Physical Properties PSA 53.17000 LogP 3.11400 Appearance of Characters white to yellow InChIKey RURAZZMDMNRXMI-UHFFFAOYSA-N Storage condition Desiccate at RT Safety Information Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter RIDADR NONH for all modes of transport HS Code 2933990090 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 20.0% |
| Transport Info | Product name: Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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