![N-(3-(5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide structure, CAS 918504-65-1](/structures/180000/177133_1_918504_65_1.png)
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 918504-65-1 |
| Catalog No. | 2A-2176606 |
| Chinese Name | 维罗非尼 |
| Synonyms | Zelboraf; Vemurafenib (PLX4032,RG7204); PLX4032 |
| Molecular Formula | C23H18O3N3Cl1S1F2 |
| Molecular Weight | 489.93 |
| Density | 1.5±0.1 g/cm3 |
| Boiling Point | 711.4±70.0 °C at 760 mmHg |
| Melting Point | 260-262 °C |
| Storage Condition | -20°C |
| Application | Vemurafenib is a potent B-RAF inhibitor that inhibits the activity of RAFV600E and c-RAF-1 with IC50 of 31 nM and 48 nM, respectively. |
| HTC | 2935009090 |
| MDL Number | MFCD18074504 |
| SMILES | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)c2c[nH]c3ncc(-c4ccc(Cl)cc4)cc23)c1F |
| InChI Key | GPXBXXGIAQBQNI-UHFFFAOYSA-N |
| MSDS | msds/177133_1_918504_65_1.pdf |
| Use of | Vemurafenib is a novel and potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively. Properties Name vemurafenib Synonym More Synonyms Vemurafenib (PLX4032) Biological Activity Description Vemurafenib is a novel and potent inhibitor of B-RAF kinase, with IC50s of 31 and 48 nM for RAFV600E and c-RAF-1, respectively. Related Catalog Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> MAPK/ERK Pathway >> Raf Research Areas >> Cancer B-RafV600E:31 nM (IC50) c-Raf-1:48 nM (IC50) References [1]. Bollag G, et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature, 2010, 467(7315), 596-599. [2]. Yang H, et al. RG7204 (PLX4032), a selective BRAFV600E inhibitor, displays potent antitumor activity in preclinical melanoma models. Cancer Res, 2010, 70(13), 5518-5527. [3]. Prahallad A, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature, 2012, 483(7387), 100-103. Chemical & Physical Properties Exact Mass 489.072540 PSA 100.30000 Index of Refraction 1.653 InChIKey GPXBXXGIAQBQNI-UHFFFAOYSA-N Safety Information HS Code 2935009090 |
| Tax Rebate | 9.0% |
| Supervision | None MFN tariff: 6.5% Ordinary tariff: 35.0% |
| Transport Info | Product name: Summary 2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0% |
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