| Chemical & Physical Properties | |
|---|---|
| CAS Number | 120685-11-2 |
| Catalog No. | 2A-2176594 |
| Chinese Name | 米哚妥林 |
| Synonyms | 4'-N-benzoylstaurosporine; Cgp 41 251; Midostaurin; 4'-N-benzoyl staurosprine; Benzoylstaurosporine; PKC412; PKC-412 |
| Molecular Formula | C35H30N4O4 |
| Molecular Weight | 570.64 |
| Purity | ≥98 (HPLC) |
| Density | 1.5±0.1 g/cm3 |
| Appearance | solid |
| Storage Condition | -20℃ |
| Application | Midostaurin (CGP41231; PKC412) is a multi-target protein kinase inhibitor that inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50 of 16-500 nM. |
| MDL Number | MFCD00871372 |
| SMILES | [n]21c3c4[n](c7c(c4c8c(c3c9c2cccc9)CNC8=O)cccc7)[C@@H]5O[C@]1([C@@]([C@@H]5N(C)C(=O)c6ccccc6)(OC)C)C |
| InChI | 1S/C35H30N4O4/c1-34(42-4)30(37(3)32(41)19-12-6-5-7-13-19)33-38-23-16-10-8-14-20(23)26-27-22(18-36-31(27)40)25-21-15-9-11-17-24(21)39(29(25)28(26)38)35(34,2)43-33/h5-17,30,33H,18H2,1-4H3,(H,36,40)/t30-,33-,34-,35+/m1/s1 |
| InChI Key | IIQIEMHSDLLZQA-QZPVEUDVSA-N |
| NACRES Code | NA.77 |
| UNSPSC | 12352200 |
| MSDS | msds/177121_1_120685_11_2.pdf |
| Transport Info | Product Name: Midostaurin |
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