CAS Number90-05-1
Synonyms5-fluoro-2,3-dihydro-1h-isoindole; 2-Methoxyphenol; methoxyphenol; 2,3-dihydro-6-fluoro-1H-indole; o-Methoxyphenol; Guaiacol; MFCD00002185; 2-Hydroxyanisole; 2-Methoxy-phenol; o-Methylcatechol; 2,3-dihydro-6-fluoroindole; Catechol, Methyl; o-methoxy-Phenol; 6-Fluor-indolin; 6-Fluoroindoline; ORTHO-METHOXYPHENOL; 6-fluoro-2,3-dihydro-indole; o-methoxy catechol; O-Methyl catechol; Indoline,6-fluoro; Methylcatechol; EINECS 201-964-7; Catechol monomethyl ether; o-Hydroxyanisole
Molecular Formula(CH3O)C6H4OH
Molecular Weight124.14
Purity≥98.0%
Density1.2±0.1 g/cm3
Boiling Point205 °C (lit.)
Melting Point26-29 °C (lit.)
Appearanceliquid
EINECS201-964-7
Symbol
Signal WordWarning
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 90-05-1 |
| Catalog No. | 2A-9017649 |
| Chinese Name | 愈创木酚 |
| Synonyms | 5-fluoro-2,3-dihydro-1h-isoindole; 2-Methoxyphenol; methoxyphenol; 2,3-dihydro-6-fluoro-1H-indole; o-Methoxyphenol; Guaiacol; MFCD00002185; 2-Hydroxyanisole; 2-Methoxy-phenol; o-Methylcatechol; 2,3-dihydro-6-fluoroindole; Catechol, Methyl; o-methoxy-Phenol; 6-Fluor-indolin; 6-Fluoroindoline; ORTHO-METHOXYPHENOL; 6-fluoro-2,3-dihydro-indole; o-methoxy catechol; O-Methyl catechol; Indoline,6-fluoro; Methylcatechol; EINECS 201-964-7; Catechol monomethyl ether; o-Hydroxyanisole |
| Molecular Formula | (CH3O)C6H4OH |
| Molecular Weight | 124.14 |
| Purity | ≥98.0 |
| Density | 1.2±0.1 g/cm3 |
| Boiling Point | 205 °C (lit.) |
| Melting Point | 26-29 °C (lit.) |
| Appearance | liquid |
| Water Solubility | 17 g/L (15 ºC) |
| Storage Condition | 1. Light-sealed packaging. Store in a cool, dark p |
| Packaging | II |
| Application | Guaiacol is a phenolic compound isolated from guaiac resin that inhibits LPS-stimulated COX-2 expression and NF-κB activation [1]. Has anti-inflammatory activity [1]. |
| EINECS | 201-964-7 |
| HTC | 2909500000 |
| PubChem ID | 24895212 |
| MDL Number | MFCD00002185 |
| SMILES | COc1ccccc1O |
| InChI | 1S/C7H8O2/c1-9-7-5-3-2-4-6(7)8/h2-5,8H,1H3 |
| InChI Key | LHGVFZTZFXWLCP-UHFFFAOYSA-N |
| Beilstein/REAXYS | 508112 |
| NACRES Code | NA.77 |
| UNSPSC | 12352202 |
| Hazard Symbols | 6.1(b) |
| MSDS | msds/17649_1_90_05_1.pdf |
| Bioactivity | Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1]. Related Catalog Natural Products >> Phenols Research Areas >> Inflammation/Immunology Target COX-2 NF-κB In Vitro Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) > Vanillin (>500 μM) > Guaiacol (72 μM) > Eugenol (12 μM)[1]. References [1]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Boiling Point 207.5±29.0 °C at 760 mmHg Melting Point 26-29 °C(lit.) Molecular Formula C7H8O2 Molecular Weight 124.14 Flash Point 79.3±24.3 °C PSA 29.46000 LogP 2.11 Vapour density 4.27 (vs air) Vapour Pressure 0.2±0.4 mmHg at 25°C Index of Refraction 1.538 InChIKey LHGVFZTZFXWLCP-UHFFFAOYSA-N SMILES COc1ccccc1O Storage condition Refrigerator Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents. Water Solubility 17 g/L (15 ºC) Freezing Point 28℃ |
| Use of | Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1]. Properties Articles125 Name guaiacol Synonym More Synonyms Guaiacol Biological Activity Description Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1]. Related Catalog Natural Products >> Phenols Research Areas >> Inflammation/Immunology References [1]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7. Chemical & Physical Properties Molecular Formula C7H8O2 PSA 29.46000 Vapour density 4.27 (vs air) Index of Refraction 1.538 InChIKey LHGVFZTZFXWLCP-UHFFFAOYSA-N Storage condition Refrigerator Stability Stable, but air and light sensitive. Combustible. Incompatible with strong oxidizing agents. Freezing Point 28℃ |
| Tax Rebate | 9.0% |
| Supervision | None. MFN tariff: 5.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Purity: 0.0% |
| MSDS Transport Info | Module 14. Shipping information United Nations classification: inconsistent with United Nations classification standards UN number: not specified |
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