| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1405-97-6 |
| Catalog No. | 2A-3175159 |
| Chinese Name | 短杆菌肽 |
| Synonyms | GRAMICIDIN (gramicidin A shown); GRAMICIDINE; GRAMICIDIN |
| Molecular Formula | C99H140N20O17 |
| Molecular Weight | 1882.29000 |
| Melting Point | 229-230℃ |
| Appearance | powder |
| Water Solubility | Practically insoluble in water, soluble in methano |
| Storage Condition | 2-8°C |
| Application | Gramicidin is an antimicrobial peptide that assembles into channels in membranes and increases their permeability to cations. |
| MDL Number | MFCD00131232 |
| SMILES | [nH]1c2c(c(c1)C[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)C)CC(C)C)C)C(C)C)C(C)C)C(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc7c8c([nH]c7)cccc8)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](Cc5c6c([nH]c5) |
| InChI | 1S/C99H140N20O17/c1-51(2)37-73(109-86(123)59(17)107-81(122)49-105-96(133)82(55(9)10)106-50-121)89(126)108-60(18)87(124)117-84(57(13)14)98(135)119-85(58(15)16)99(136)118-83(56(11)12)97(134)116-80(44-64-48-104-72-34-26-22-30-68(64)72)95(132)112-76(40-54(7)8)92(129)115-79(43-63-47-103-71-33-25-21-29-67(63)71)94(131)111-75(39-53(5)6)91(128)114-78(42-62-46-102-70-32-24-20-28-66(62)70)93(130)110-74(38-52(3)4)90(127)113-77(88(125)100-35-36-120)41-61-45-101-69-31-23-19-27-65(61)69/h19-34,45-48,50-60,73-80,82-85,101-104,120H,35-44,49H2,1-18H3,(H,100,125)(H,105,133)(H,106,121)(H,107,122)(H,108,126)(H,109,123)(H,110,130)(H,111,131)(H,112,132)(H,113,127)(H,114,128)(H,115,129)(H,116,134)(H,117,124)(H,118,136)(H,119,135)/t59-,60-,73+,74+,75+,76+,77-,78-,79-,80-,82-,83-,84+,85-/m0/s1 |
| InChI Key | ZWCXYZRRTRDGQE-SORVKSEFSA-N |
| NACRES Code | NA.24 |
| UNSPSC | 41116107 |
| MSDS | msds/175574_1_1405_97_6.pdf |
| Bioactivity | Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Target Bacterial[1] In Vitro Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. There is poor Gramicidin activity against E. coli and S. cerevisae as shown from the survival of microbes (%) over a range of Gramicidin concentrations, in contrast with the action of Gramicidin on S. aureus. The microbicidal activity occurs over a range of low Gramicidin and DODAB concentrations which are not toxic to S. cerevisae[1]. Cell Assay Microbes and dispersions are mixed and interacted for one hour before being diluted up to 20,000-fold for plating of 0.1 mL of each in triplicate and incubation (24 hours for 37°C) for CFU counting. Cell survival (%), taken as the mean±standard deviation, is plotted against DODAB and/or Gramicidin concentration. As a control for cell viability in the absence of DODAB or DODAB/Gramicidin dispersions, a standard bacterial suspension is added to 0.264 M D-glucose solution, diluted, and spreaded on the agar plate[1]. References [1]. Ragioto DA, et al. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. Int J Nanomedicine. 2014 Jun 30;9:3183-92. Chemical & Physical Properties Melting Point 229-230℃ Molecular Formula C99H140N20O17 Molecular Weight 1882.29000 Exact Mass 1881.07000 PSA 548.99000 LogP 11.26260 Vapour Pressure 0mmHg at 25°C InChIKey ZWCXYZRRTRDGQE-SORVKSEFSA-N SMILES CC(C)CC(NC(=O)C(C)NC(=O)CNC(=O)C(NC=O)C(C)C)C(=O)NC(C)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NC(CC(C)C)C(=O)NC(Cc1c[nH]c2ccccc12)C(=O)NCCO)C(C)C)C(C)C)C(C)C Storage condition 2-8°C Water Solubility Practically insoluble in water, soluble in methanol, sparingly soluble in alcohol | Soluble in acetic acid and lower alcohols. Practically insoluble in water. |
| Use of | Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. Properties Articles50 Name Gramicidin A Synonym More Synonyms Gramicidin TFA Biological Activity Description Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. Related Catalog Signaling Pathways >> Anti-infection >> Bacterial Research Areas >> Infection Bacterial[1] In Vitro Gramicidin is an antimicrobial peptide assembling as channels in membranes and increasing their permeability towards cations. There is poor Gramicidin activity against E. coli and S. cerevisae as shown from the survival of microbes (%) over a range of Gramicidin concentrations, in contrast with the action of Gramicidin on S. aureus. The microbicidal activity occurs over a range of low Gramicidin and DODAB concentrations which are not toxic to S. cerevisae[1]. References [1]. Ragioto DA, et al. Novel gramicidin formulations in cationic lipid as broad-spectrum microbicidal agents. Int J Nanomedicine. 2014 Jun 30;9:3183-92. Chemical & Physical Properties Molecular Formula C99H140N20O17 Exact Mass 1881.07000 PSA 548.99000 LogP 11.26260 InChIKey ZWCXYZRRTRDGQE-SORVKSEFSA-N Water Solubility Practically insoluble in water, soluble in methanol, sparingly soluble in alcohol | Soluble in acetic acid and lower alcohols. Practically insoluble in water. |
| Transport Info | Product Name: Gramicidin TFA |
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