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Home > Products > Pharmaceutical R&D Materials > Heterocyclic Building Blocks > 3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide
3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide structure, CAS 348622-88-8

3-(Aminocarbonyl)-β-(3-cyclohexylpropyl)-N-hydroxy-1,2,4-oxadiazole-5-propanamide

CAS Number348622-88-8

SynonymsCS-0414; UK383367; S2224_Selleck; 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide; UK 383367; 5-[(3R)-6-Cyclohexyl-1-(hydroxyamino)-1-oxo-3-hexanyl]-1,2,4-oxadiazole-3-carboxamide; UK-383367

Molecular FormulaC15H24N4O4

Molecular Weight324.38

Purity≥98 (HPLC)%

Density1.2±0.1 g/cm3

Boiling Point

Melting Point136-138℃

Flash Point

Appearancepowder

EINECS

MSDSChineseEnglish

Symboltransportation

Signal WordWarning

Cat. No.: 2A-1175019 Purity: ≥98 (HPLC)%
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Quality Control of [ 348622-88-8 ] Purity: ≥98 (HPLC)% SDS Specification MoL

COA NMR CNMR HPLC LC-MS
Chemical & Physical Properties
CAS Number348622-88-8
Catalog No.2A-1175019
Chinese Name5-[(1R)-4-环己基-1-[2-(羟基氨基)-2-氧代乙基]丁基]-1,2,4-恶二唑-3-甲酰胺
SynonymsCS-0414; UK383367; S2224_Selleck; 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide; UK 383367; 5-[(3R)-6-Cyclohexyl-1-(hydroxyamino)-1-oxo-3-hexanyl]-1,2,4-oxadiazole-3-carboxamide; UK-383367
Molecular FormulaC15H24N4O4
Molecular Weight324.38
Purity≥98 (HPLC)
Density1.2±0.1 g/cm3
Melting Point136-138℃
Appearancepowder
Water SolubilityDMSO: >30mg/mL
Storage ConditionStore at -20°C
PubChem ID329823739
MDL NumberMFCD19690945
SMILESNC(=O)c1noc(n1)[C@H](CCCC2CCCCC2)CC(=O)NO
InChI1S/C15H24N4O4/c16-13(21)14-17-15(23-19-14)11(9-12(20)18-22)8-4-7-10-5-2-1-3-6-10/h10-11,22H,1-9H2,(H2,16,21)(H,18,20)/t11-/m1/s1
InChI KeyARJCBSRIPGJMAD-LLVKDONJSA-N
NACRES CodeNA.77
UNSPSC41121800
Hazard Symbolstransportation
MSDSmsds/175423_1_348622_88_8.pdf
BioactivityUK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Procollagen C Proteinase Research Areas >> Others References [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418. [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562. Chemical & Physical Properties Density 1.2±0.1 g/cm3 Melting Point 136-138℃ Molecular Formula C15H24N4O4 Molecular Weight 324.375 Exact Mass 324.179749 PSA 134.83000 LogP 1.37 Appearance of Characters white to off-white Index of Refraction 1.541 InChIKey ARJCBSRIPGJMAD-LLVKDONJSA-N SMILES NC(=O)c1noc(C(CCCC2CCCCC2)CC(=O)NO)n1 Storage condition Store at -20°C Water Solubility DMSO: >30mg/mL
Use ofUK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent Properties Name 5-[(3R)-6-cyclohexyl-1-(hydroxyamino)-1-oxohexan-3-yl]-1,2,4-oxadiazole-3-carboxamide Synonym More Synonyms UK 383367 Biological Activity Description UK-383367 (UK 383367) is a potent and selective inhibitor of BMP-1 (procollagen C-proteinase) with IC50 of 44 nM; Selective for BMP-1 over MMPs 1, 2, 3, 9 and 14 (IC50 values are >10,000 nM for listed MMPs).IC50 value: 44 nMTarget: procollagen C-proteinaseUK-383367 (UK 383367) is useful for anti-scarring agent Related Catalog Signaling Pathways >> Metabolic Enzyme/Protease >> Procollagen C Proteinase Research Areas >> Others References [1]. Allan GA, Gedge JI, Nedderman AN, Roffey SJ, Small HF, Webster R.Pharmacokinetics and metabolism of UK-383,367 in rats and dogs: a rationale for long-lived plasma radioactivity.Xenobiotica. 2006 May;36(5):399-418. [2]. Bailey et al (2008) Succinyl hydroxamates as potent and selective non-peptidic inhibitors of procollagen C-proteinase: design, synthesis, and evaluation as topically applied, dermal anti-scarring agents. Bioorg.Med.Chem.Lett. 18 6562. Chemical & Physical Properties Molecular Formula C15H24N4O4 Exact Mass 324.179749 PSA 134.83000 Appearance of Characters white to off-white Index of Refraction 1.541 InChIKey ARJCBSRIPGJMAD-LLVKDONJSA-N
Transport InfoProduct name: Purity: 99.0%
MSDS Transport InfoModule 14. Shipping information European Dangerous Regulations for land transport: 2811 International Dangerous Regulations for sea transport: 2811 International Dangerous Regulations for air transport: 2811 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: TOXIC SOLID, ORGANIC, N.O.S. (UK-383,367) IMDG: TOXIC SOLID, ORGANIC, N.O.S. (UK-383,367) International air transport hazard regulations: Toxic solid, organic, n.o.s. (UK-383,367) 14.3 Transport hazard categories European Land Transport Danger Regulations: 6.1 International Maritime Transport Danger Regulations: 6.1 International Air Transport Danger Regulations: 6.1 14.4 Package group European Land Transport Danger Regulations: III International Maritime Transport Danger Regulations: III International Air Transport Danger Regulations: III 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available
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