| Chemical & Physical Properties | |
|---|---|
| CAS Number | 843666-40-0 |
| Catalog No. | 2A-3174914 |
| Chinese Name | 十八烷二酸单叔丁酯 |
| Synonyms | Octadecanedioic acid,1-(1,1-dimethylethyl) ester; Octadecanedioic acid mono-tert-butyl ester; 18-tert-butoxy-18-oxooctadecanoic acid |
| Molecular Formula | C22H42O4 |
| Molecular Weight | 370.57 |
| Appearance | White to yellow solid |
| Storage Condition | Room temperature, dry, sealed |
| Application | Boc-C16-COOH is a non-cleavable ADC linker for the synthesis of antibody drug conjugates (ADC). Boc-C16-COOH is also a PROTAC linker based on an alkyl chain and can be used to synthesize PROTAC[1] |
| HTC | 2918990090 |
| PubChem ID | 60195943 |
| MDL Number | MFCD09991735 |
| SMILES | CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)O |
| InChI | InChI=1S/C22H42O4/c1-22(2,3)26-21(25)19-17-15-13-11-9-7-5-4-6-8-10-12-14-16-18-20(23)24/h4-19H2,1-3H3,(H,23,24) |
| InChI Key | WDUQJXKBWRNMKI-UHFFFAOYSA-N |
| MSDS | msds/175302_1_843666_40_0.pdf |
| Use of | Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] Properties Name 18-[(2-methylpropan-2-yl)oxy]-18-oxooctadecanoic acid Synonym More Synonyms Boc-C16-COOH Biological Activity Description Boc-C16-COOH is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Boc-C16-COOH is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1] Related Catalog Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker Non-cleavable In Vitro ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. References [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. Chemical & Physical Properties Molecular Formula C22H42O4 Exact Mass 370.30800 PSA 63.60000 LogP 6.65430 InChIKey WDUQJXKBWRNMKI-UHFFFAOYSA-N SMILES CC(C)(C)OC(=O)CCCCCCCCCCCCCCCCC(=O)O Safety Information Hazard Codes Xn HS Code 2918990090 Synthetic Route Total: 1 Page Octadecanedioic acid CAS#:871-70-5 1,1-Di-tert-but... CAS#:36805-97-7 Boc-C16-COOH CAS#:843666-40-0 Precursor & DownStream Precursor 2 CAS#:871-70-5 Octadecanedioic acid CAS#:36805-97-7 1,1-Di-tert-but... DownStream 0 |
| Tax Rebate | 13.0% |
| Supervision | None. MFN tariff: 6.5%. Ordinary tariff: 30.0% |
| Transport Info | Product name: Summary 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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