| Chemical & Physical Properties | |
|---|---|
| CAS Number | 1802220-02-5 |
| Catalog No. | 2A-1174502 |
| Chinese Name | 洛普替尼 |
| Synonyms | 08O3FQ4UNP; Repotrectinib |
| Molecular Formula | C18H18O2N5F1 |
| Molecular Weight | 355.37 |
| Density | 1.5±0.1 g/cm3 |
| Appearance | powder |
| Storage Condition | -20℃ |
| Application | Repotrectinib (TPX-0005) is a potent ALK/ROS1/TRK inhibitor with IC50 values of 5.3 nM, 1.01 nM, 1.26 nM and 1.08 nM against SRC, wild-type WT ALK, mutant ALK G1202R and ALK L1196M, respectively. |
| PubChem ID | 85736922 |
| MDL Number | MFCD31544350 |
| InChI | InChI=1S/C18H18FN5O2/c1-10-8-20-18(25)14-9-21-24-6-5-16(23-17(14)24)22-11(2)13-7-12(19)3-4-15(13)26-10/h3-7,9-11H,8H2,1-2H3,(H,20,25)(H,22,23)/t10-,11+/m0/s1 |
| InChI Key | FIKPXCOQUIZNHB-WDEREUQCSA-N |
| MSDS | msds/174855_1_1802220_02_5.pdf |
| Transport Info | Product name: Lopotinib (TPX-0005) |
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