CAS Number85-61-0
SynonymsCoalip; COA-SH; coenzyme-A; EINECS 201-619-0; CoASH; Lucina; CoA; Thiol-CoA; co-enzyme-A; MFCD06795839; HSCoA; HS-CoA; CONENZYME A; Coenzyme A; Aluzime; Coenzym A
Molecular FormulaC21H36N7O16P3S
Molecular Weight767.53 (anhydrous basis)
Purity≥85 (UV, HPLC)%
Density2.0±0.1 g/cm3
Boiling Point146 - 147
Melting Point-5ºC
Appearancepowder
Symbol
Signal WordWarning
Please Login or Create an Account to: See VlP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
| Chemical & Physical Properties | |
|---|---|
| CAS Number | 85-61-0 |
| Catalog No. | 2A-9017455 |
| Chinese Name | 辅酶A |
| Synonyms | Coalip; COA-SH; coenzyme-A; EINECS 201-619-0; CoASH; Lucina; CoA; Thiol-CoA; co-enzyme-A; MFCD06795839; HSCoA; HS-CoA; CONENZYME A; Coenzyme A; Aluzime; Coenzym A |
| Molecular Formula | C21H36N7O16P3S |
| Molecular Weight | 767.53 (anhydrous basis) |
| Purity | ≥85 (UV, HPLC) |
| Density | 2.0±0.1 g/cm3 |
| Boiling Point | 146 - 147 |
| Melting Point | -5ºC |
| Appearance | powder |
| Storage Condition | Seal and store in a dry place at 4°C away from lig |
| Application | Coenzyme A is an essential cofactor in all living cells synthesized from pantothenic acid (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to peroxidase 5 (Prdx5 |
| PubChem ID | 24892684 |
| MDL Number | MFCD06795839 |
| SMILES | O.CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n2cnc3c(N)ncnc23)[C@@H](O)C(=O)NCCC(=O)NCCS |
| InChI | 1S/C21H36N7O16P3S.H2O/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);1H2/t11-,14-,15-,16+,20-;/m1./s1 |
| InChI Key | TVSAELAFGDOPKI-BLPRJPCASA-N |
| Beilstein/REAXYS | 77809 |
| NACRES Code | NA.21 |
| UNSPSC | 12352100 |
| Hazard Symbols | Transport |
| MSDS | msds/17455_1_85_61_0.pdf |
| Bioactivity | Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Baković J, et al. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Mol Cell Biochem. 2019 Aug 2. Chemical & Physical Properties Density 2.0±0.1 g/cm3 Boiling Point 146 - 147 Melting Point -5ºC Molecular Formula C21H36N7O16P3S Molecular Weight 767.534 Exact Mass 767.115234 PSA 414.79000 LogP -4.02 Index of Refraction 1.737 InChIKey RGJOEKWQDUBAIZ-LMNWYZMXSA-N SMILES CC(C)(COP(=O)(O)OP(=O)(O)OCC1OC(n2cnc3c(N)ncnc32)C(O)C1OP(=O)(O)O)C(O)C(=O)NCCC(=O)NCCS Storage condition −20°C |
| Use of | Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1]. Properties Name coenzyme A Synonym More Synonyms Coenzyme A Biological Activity Description Coenzyme A is is an obligatory cofactor in all living cells synthesised from pantothenate (Vitamin B5), adenosine triphosphate (ATP) and cysteine. Covalent binding of Coenzyme A to Peroxiredoxin 5 (Prdx5) results in complete inhibition of its peroxidase activity, which is reversed by reduction with DTT.Coenzyme A and its thioester derivatives are key players in major catabolic and anabolic pathways and the regulation of gene expression. Many human pathologies, including cancer, diabetes and neurodegeneration, have been associated with abnormal biosynthesis and homeostasis of CoA and its derivatives[1]. Related Catalog Research Areas >> Cancer Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease References [1]. Baković J, et al. A key metabolic integrator, coenzyme A, modulates the activity of peroxiredoxin 5 via covalent modification. Mol Cell Biochem. 2019 Aug 2. Chemical & Physical Properties Molecular Formula C21H36N7O16P3S Exact Mass 767.115234 PSA 414.79000 LogP -4.02 Index of Refraction 1.737 InChIKey RGJOEKWQDUBAIZ-LMNWYZMXSA-N |
| Transport Info | Product name: Purity: 85.0% |
| MSDS Transport Info | Module 14. Shipping information 14.1 UN dangerous goods number European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.2 Names specified by the United Nations (UN) European Land Transport Dangerous Regulations: Non-dangerous goods IMDG Code: Non-dangerous goods International air transport dangerous goods regulations: non-dangerous goods 14.3 Transport hazard categories European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.4 Package group European Land Transport Dangerous Regulations: -International Maritime Dangerous Regulations: -International Air Transport Dangerous Regulations: - 14.5 Environmental hazards European Land Transport Dangerous Regulations: No International Maritime Transport Dangerous Regulations Maritime Pollutants: No International Air Transport Risk Regulations: No 14.6 Special reminder to users No data available |
| Related Products in Specialty Chemicals | ||
|---|---|---|
| 2-Benzoylbenzoic acid | 85-52-9 | 2A-9017449 |
| 2-(4-Chloro-3-nitrobenzoyl)benzoic acid | 85-54-1 | 2A-9017450 |
| 2-(4-Methylbenzoyl)benzoic acid | 85-55-2 | 2A-9017451 |
| 2-(4-Chlorobenzoyl)benzoic acid | 85-56-3 | 2A-9017452 |
| 4,4'-Butylidenebis(6-tert-butyl-3-methylphenol) | 85-60-9 | 2A-9017454 |
| Butyl benzyl phthalate | 85-68-7 | 2A-9017456 |
| 1-(2-Pyridylazo)-2-naphthol | 85-85-8 | 2A-9017462 |
| Methyl 2-(methylamino)benzoate | 85-91-6 | 2A-9017464 |
| 1,3-Diethyl-1,3-diphenylurea | 85-98-3 | 2A-9017465 |
| 2-Nitrodiphenyl | 86-00-0 | 2A-9017466 |
| Browse all Specialty Chemicals products » | ||
Phone:
630-322-8886
630-322-8887
Email:
Office Locations:
Chicago, IL, USA
San Francisco, CA, USA
EN
SDS